Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10-deficient mice

被引：28

作者：

Agnello, D

Villa, P

Ghezzi, P

机构：

[1] Mario Negri Inst Pharmacol Res, Lab Neuroimmunol, I-20157 Milan, Italy

[2] CNR, Cellular & Mol Pharmacol Ctr, I-20129 Milan, Italy

来源：

BRAIN RESEARCH | 2000年 / 869卷 / 1-2期

关键词：

D O I：

10.1016/S0006-8993(00)02392-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin-10 (IL-10) inhibits tumor necrosis factor (TNF) production. We investigated the role of endogenous IL-IO in brain TNF production. We injected IL-10-knockout mice with lipopolysaccharide (LPS,2.5 mu g/mouse i.c.v.). Brain TNF and IL-6 levels were more elevated and persisted longer in IL-10-deficient mice compared with wild type mice, suggesting that IL-10 is an important negative feedback inhibitor of TNF and IL-6 production in the CNS. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：241 / 243

页数：3

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