Hydrodynamic narrowing of tubes extruded from cells

被引：99

作者：

Brochard-Wyart, F ^{[1
]}

Borghi, N ^{[1
]}

Cuvelier, D ^{[1
]}

Nassoy, P ^{[1
]}

机构：

[1] Inst Curie, Lab Physicochim Curie, CNRS, UMR 168, F-75231 Paris 5, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 20期

关键词：

cytoskeleton; dynamics; membrane tethers;

D O I：

10.1073/pnas.0602012103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

We discuss the pulling force f required to extrude a lipid tube from a living cell as a function of the extrusion velocity L The main feature is membrane friction on the cytoskeleton. As recently observed for neutrophils, the tether force exhibits a "shear thinning" response over a large range of pulling velocities, which was previously interpreted by assuming viscoelastic flows of the sliding membrane. Here, we propose an alternative explanation based on purely Newtonian flow: The diameter of the tether decreases concomitantly with the increase of the membrane tension in the lipid tube. The pulling force is found to vary as L-1/3, which is consistent with reported experimental data for various types of cells.

引用

页码：7660 / 7663

页数：4

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