A novel chiral pentamine ligand for enantioselective α-alkylation of acyclic lithium amide enolates.: Optimization of chiral ligands for asymmetric reactions using solid-phase organic synthesis

被引：17

作者：

Matsuo, J ^{[1
]}

Odashima, K ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1021/ol990624d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel pentamine ligand has been developed for enantioselective alpha-alkylation of simple acyclic lithium amide enolates. It has been demonstrated that solid phase organic synthesis provides a powerful and rapid method for finding efficient chiral ligands.

引用

页码：345 / 347

页数：3

共 31 条

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