The Intracellular Life of Cryptococcus neoformans

被引：97

作者：

Coelho, Carolina ^{[1
,2
,3
]}

Bocca, Anamelia L. ^{[4
]}

Casadevall, Arturo ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[2] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal

[3] Univ Coimbra, Fac Med, Inst Microbiol, P-3004504 Coimbra, Portugal

[4] Univ Brasilia, Inst Biol Sci, Dept Cellular Biol, BR-70910900 Brasilia, DF, Brazil

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 | 2014年 / 9卷

关键词：

granuloma; Trojan horse; disease tolerance; fungal immunity; intracellular pathogen; C. neoformans killing; NITRIC-OXIDE SYNTHASE; CLASSICAL MACROPHAGE ACTIVATION; PULMONARY INFLAMMATORY RESPONSE; PROTECTIVE TH1 RESPONSE; HOST-DEFENSE; ALVEOLAR MACROPHAGES; DENDRITIC CELLS; IN-VIVO; MONOCLONAL-ANTIBODIES; PHAGOSOMAL PROTEOME;

D O I：

10.1146/annurev-pathol-012513-104653

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological studies of human populations show a high prevalence of human infection, which rarely progresses to disease in immunocompetent hosts. However, decreased host immunity places individuals at high risk for cryptococcal disease. The disease can result from acute infection or reactivation of latent infection, in which yeasts within granulomas and host macrophages emerge to cause disease. In this review, we summarize what is known about the cellular recognition, ingestion, and killing of C. neoformans and discuss the unique and remarkable features of its intracellular life, including the proposed mechanisms for fungal persistence and killing in phagocytic cells.

引用

页码：219 / 238

页数：20

共 134 条

[1]

Aguirre KM, 2000, MED MYCOL, V38, P343, DOI 10.1080/mmy.38.5.343.353

[2]

INHIBITION OF CRYPTOCOCCUS-NEOFORMANS REPLICATION BY NITROGEN-OXIDES SUPPORTS THE ROLE OF THESE MOLECULES AS EFFECTORS OF MACROPHAGE-MEDIATED CYTOSTASIS [J].