Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study

被引：53

作者：

Bartoloni, Elena ^{[1
]}

Gonzalez-Gay, Miguel A. ^{[2
]}

Scire, Carlo ^{[3
]}

Castaneda, Santos ^{[4
]}

Gerli, Roberto ^{[1
]}

Javier Lopez-Longo, Francisco ^{[5
]}

Martinez-Barrio, Julia ^{[5
]}

Govoni, Marcello ^{[6
]}

Furini, Federica ^{[6
]}

Pina, Trinitario ^{[2
]}

Iannone, Florenzo ^{[7
]}

Giannini, Margherita ^{[7
]}

Nuno, Laura ^{[8
]}

Quartuccio, Luca ^{[9
]}

Ortego-Centeno, Norberto ^{[10
]}

Alunno, Alessia ^{[1
]}

Specker, Christopher ^{[11
]}

Montecucco, Carlomaurizio ^{[12
,13
]}

Triantafyllias, Konstantinos ^{[14
]}

Balduzzi, Silvia ^{[12
,13
]}

Alberto Sifuentes-Giraldo, Walter ^{[15
]}

Paolazzi, Giuseppe ^{[16
]}

Bravi, Elena ^{[17
]}

Schwarting, Andreas ^{[18
]}

Pellerito, Raffaele ^{[19
]}

Russo, Alessandra ^{[19
]}

Selmi, Carlo ^{[20
]}

Saketkoo, Lesley-Ann ^{[21
]}

Fusaro, Enrico ^{[22
]}

Parisi, Simone ^{[22
]}

Pipitone, Nicolo ^{[23
]}

Franceschini, Franco ^{[24
,25
]}

Cavazzana, Ilaria ^{[24
,25
]}

Neri, Rossella ^{[26
]}

Barsotti, Simone ^{[26
]}

Codullo, Veronica ^{[12
,13
]}

Cavagna, Lorenzo ^{[12
,13
]}

机构：

[1] Univ Perugia, Dept Med, Rheumatol Unit, Via Enrico dal Pozzo, I-06122 Perugia, Italy

[2] Univ Cantabria, IDIVAL, Hosp Univ Marques de Valdecilla, Div Rheumatol, Santander, Spain

[3] Italian Soc Rheumatol, Epidemiol Unit, Milan, Italy

[4] IIS IP, Hosp Univ Princesa, Dept Rheumatol, Madrid, Spain

[5] Hosp Gen Univ Gregorio Maranon, Serv Reumatol, Madrid, Spain

[6] Univ Ferrara, Azienda Osped Univ S Anna, UOC Reumatol, Ferrara, Italy

[7] Univ Bari, Rheumatol Unit, Interdisciplinary Dept Med DIM, Bari, Italy

[8] Hosp Univ La Paz, Serv Reumatol, Madrid, Spain

[9] Santa Maria della Misericordia Hosp, Dept Med & Biol Sci DSMB, Clin Rheumatol, Udine, Italy

[10] Hosp Clin San Cecilio, Syst Autoimmune Dis Unit, Granada, Spain

[11] St Josefs Hosp, Univ Clin, Dept Rheumatol & Clin Immunol, Essen, Germany

[12] Univ Pavia, Div Rheumatol, Pavia, Italy

[13] IRCCS Policlin S Matteo Fdn, Pavia, Italy

[14] ACURA Rheumatol Ctr, Bad Kreuznach, Germany

[15] Univ Hosp Ramon & Cajal, Dept Rheumatol, Madrid, Spain

[16] Santa Chiara Hosp, Rheumatol Unit, Trento, Italy

[17] Osped Guglielmo Saliceto, Rheumatol Unit, Piacenza, Italy

[18] Univ Hosp Johannes Gutenberg, Dept Internal Med Rheumatol & Clin Immunol, Mainz, Germany

[19] Mauriziano Hosp, Div Rheumatol, Turin, Italy

[20] Humanitas Res Hosp, Div Rheumatol & Clin Immunol, Milan, Italy

[21] Tulane Univ, Lung Ctr Tulane, UMC Scleroderma & Sarcoidosis Patient Care & Res, New Orleans, LA 70118 USA

[22] Citta Salute & Sci, Dept Rheumatol, Turin, Italy

[23] Azienda Osped ASMN, Dept Internal Med, Rheumatol Unit, Reggio Emilia, Italy

[24] Univ Brescia, Rheumatol Unit, Brescia, Italy

[25] AO Spedali Civili, Brescia, Italy

[26] Univ Pisa, Dept Clin & Expt Med, Div Rheumatol, Pisa, Italy

来源：

AUTOIMMUNITY REVIEWS | 2017年 / 16卷 / 03期

关键词：

Anti-synthetase syndrome; Raynaud's phenomenon; mechanic's hand; INTERSTITIAL LUNG-DISEASE; ANTISYNTHETASE SYNDROME; INFLAMMATORY MYOPATHY; MANIFESTATIONS; COHORT; AUTOANTIBODIES; HETEROGENEITY; PHENOTYPE; DIAGNOSIS; MYOSITIS;

D O I：

10.1016/j.autrev.2017.01.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Objective: Arthritis, myositis and interstitial lung disease (ILD) constitute the classic clinical triad of anti-synthetase syndrome (ASSD). These patients experience other accompanying features, such as Raynaud's phenomenon, fever or mechanic's hands. Most ASSD patients develop the complete triad during the follow-up. In the present study we aimed to determine whether the subsequent appearance of accompanying features may suggest the development of triad findings lacking at the onset in anti-Jo1 positive ASSD patients. Methods: Anti Jot positive patients presenting with incomplete ASSD (no >2 classic triad features) were assessed. Clinical characteristics and clusters of disease manifestations were retrospectively collected and analyzed in a large international multicenter cohort of ASSD patients. Results: 165 patients (123 women) with incomplete ASSD were identified. Ninety-five patients (57.5%) developed new classic triad manifestations after 15 months median (IQR 9-51) and 40 (24%) developed new accompanying features after 19 months median (IQR 6-56) from disease onset. During the follow-up, the ex-novo occurrence of triad features was observed in 32 out of 40 patients (80%) with new accompanying findings and in 63 out of 125 patients (50.5%) without new accompanying findings (p = 0.002). In patients with at least one new accompanying feature the odds ratio for the occurrence of new triad manifestations was 3.94 with respect to patients not developing ex-novo accompanying findings (95% CI 1.68-9.21, p = 0.002). Conclusion: Anti-Jo1 ASSD patients with incomplete forms at disease onset are at high risk for the subsequent occurrence of lacking classic triad findings. Although all ASSD patients should be carefully assessed for the occurrence of new triad features, a closer follow-up should be considered in the subgroup of patients developing ex novo accompanying findings. These patients, indeed, have near four-fold increased risk for new classic triad manifestation occurrence with respect to patients not presenting ex novo accompanying findings. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：253 / 257

页数：5

共 28 条

[1]

Long-term experience with rituximab in anti-synthetase syndrome-related interstitial lung disease [J].

Andersson, Helena ;

Sem, Marthe ;

Lund, May Brit ;

Aalokken, Trond Mogens ;

Gunther, Anne ;

Walle-Hansen, Ragnhild ;

Garen, Torhild ;

Molberg, Oyvind .

RHEUMATOLOGY, 2015, 54 (08) :1420-1428

[2]

Bachmeyer C, 2007, BRIT J DERMATOL, V156, P163

[3]

Serum Jo-1 Autoantibody and Isolated Arthritis in the Antisynthetase Syndrome: Review of the Literature and Report of the Experience of AENEAS Collaborative Group [J].

Cavagna, Lorenzo ;

Nuno, Laura ;

Scire, Carlo Alberto ;

Govoni, Marcello ;

Lopez Longo, Francisco Javier ;

Franceschini, Franco ;

Neri, Rossella ;

Castaneda, Santos ;

Sifuentes Giraldo, Walter Alberto ;

Caporali, Roberto ;

Iannone, Florenzo ;

Fusaro, Enrico ;

Paolazzi, Giuseppe ;

Pellerito, Raffaele ;

Schwarting, Andreas ;

Saketkoo, Lesley Ann ;

Ortego-Centeno, Norberto ;

Quartuccio, Luca ;

Bartoloni, Elena ;

Specker, Christof ;

Pina Murcia, Trinitario ;

La Corte, Renato ;

Furini, Federica ;

Foschi, Valentina ;

Bachiller Corral, Javier ;

Airo, Paolo ;

Cavazzana, Ilaria ;

Martinez-Barrio, Julia ;

Hinojosa, Michelle ;

Giannini, Margherita ;

Barsotti, Simone ;

Menke, Julia ;

Triantafyllias, Kostantinos ;

Vitetta, Rosetta ;

Russo, Alessandra ;

Bogliolo, Laura ;

Bajocchi, Gianluigi ;

Bravi, Elena ;

Barausse, Giovanni ;

Bortolotti, Roberto ;

Selmi, Carlo ;

Parisi, Simone ;

Salaffi, Fausto ;

Montecucco, Carlomaurizio ;

Angel Gonzalez-Gay, Miguel .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2017, 52 (01) :71-80

[4]

Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome Results From an International Retrospective Multicenter Study [J].

Cavagna, Lorenzo ;

Nuno, Laura ;

Scire, Carlo Alberto ;

Govoni, Marcello ;

Lopez Longo, Francisco Javier ;

Franceschini, Franco ;

Neri, Rossella ;

Castaneda, Santos ;

Sifuentes Giraldo, Walter Alberto ;

Caporali, Roberto ;

Iannone, Florenzo ;

Fusaro, Enrico ;

Paolazzi, Giuseppe ;

Pellerito, Raffaele ;

Schwarting, Andreas ;

Saketkoo, Lesley Ann ;

Ortego-Centeno, Norberto ;

Quartuccio, Luca ;

Bartoloni, Elena ;

Specker, Christof ;

Pina Murcia, Trinitario ;

La Corte, Renato ;

Furini, Federica ;

Foschi, Valentina ;

Bachiller Corral, Javier ;

Airo, Paolo ;

Cavazzana, Ilaria ;

Martinez-Barrio, Julia ;

Hinojosa, Michelle ;

Giannini, Margherita ;

Barsotti, Simone ;

Menke, Julia ;

Triantafyllias, Kostantinos ;

Vitetta, Rosetta ;

Russo, Alessandra ;

Bajocchi, Gianluigi ;

Bravi, Elena ;

Barausse, Giovanni ;

Bortolotti, Roberto ;

Selmi, Carlo ;

Parisi, Simone ;

Montecucco, Carlomaurizio ;

Angel Gonzalez-Gay, Miguel .

MEDICINE, 2015, 94 (32)

[5]

Cyclosporine in Anti-Jo1-positive Patients with Corticosteroid-refractory Interstitial Lung Disease [J].

Cavagna, Lorenzo ;

Caporali, Roberto ;

Abdi-Ali, Lul ;

Dore, Roberto ;

Meloni, Federica ;

Montecucco, Carlomaurizio .

JOURNAL OF RHEUMATOLOGY, 2013, 40 (04) :484-492

[6]

Pulmonary arterial hypertension in antisynthetase syndrome: comment on the article by Chatterjee and Farver [J].

Cavagna, Lorenzo ;

Prisco, Elena ;

Montecucco, Carlomaurizio ;

Caporali, Roberto .

ARTHRITIS CARE & RESEARCH, 2011, 63 (04) :633-634

[7]

Antisynthetase syndrome: Not just an inflammatory myopathy [J].

Chatterjee, Soumya ;

Prayson, Richard ;

Farver, Carol .

CLEVELAND CLINIC JOURNAL OF MEDICINE, 2013, 80 (10) :655-666

[8]

Clinical heterogeneity and prognostic features of South Australian patients with anti-synthetase autoantibodies [J].

Dugar, M. ;

Cox, S. ;

Limaye, V. ;

Blumbergs, P. ;

Roberts-Thomson, P. J. .

INTERNAL MEDICINE JOURNAL, 2011, 41 (09) :674-679

[9]

Common and Distinct Clinical Features in Adult Patients with Anti-Aminoacyl-tRNA Synthetase Antibodies: Heterogeneity within the Syndrome [J].

Hamaguchi, Yasuhito ;

Fujimoto, Manabu ;

Matsushita, Takashi ;

Kaji, Kenzo ;

Komura, Kazuhiro ;

Hasegawa, Minoru ;

Kodera, Masanari ;

Muroi, Eiji ;

Fujikawa, Keita ;

Seishima, Mariko ;

Yamada, Hidehiro ;

Yamada, Ryo ;

Sato, Shinichi ;

Takehara, Kazuhiko ;

Kuwana, Masataka .

PLOS ONE, 2013, 8 (04)

[10]

Sera From Anti-Jo-1-Positive Patients With Polymyositis and Interstitial Lung Disease Induce Expression of Intercellular Adhesion Molecule 1 in Human Lung Endothelial Cells [J].

Helmers, Sevim Barbasso ;

Englund, Pernilla ;

Engstrom, Marianne ;

Ahlin, Erik ;

Fathi, Maryam ;

Janciauskiene, Sabina ;

Heimburger, Mikael ;

Ronnelid, Johan ;

Lundberg, Ingrid E. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (08) :2524-2530

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