Cytokine production by the murine macrophage cell line J774.1 after exposure to lactobacilli

被引：108

作者：

Morita, H

He, F ^{[1
]}

Fuse, T

Ouwehand, AC

Hashimoto, H

Hosoda, M

Mizumachi, K

Kurisaki, JI

机构：

[1] Takanashi Milk Prod Co Ltd, Tech Res Lab, Yokohama, Kanagawa 2410023, Japan

[2] Univ Turku, Dept Biochem, FIN-20014 Turku, Finland

[3] Univ Turku, Dept Food Chem, FIN-20014 Turku, Finland

[4] Natl Inst Livestock & Grassland Sci, Inashiki, Ibaraki 3050901, Japan

[5] Natl Inst Agrobiol Sci, Tsukuba, Ibaraki 3058602, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2002年 / 66卷 / 09期

关键词：

cytokine; macrophage; Lactobacillus; inflammation; probiotics;

D O I：

10.1271/bbb.66.1963

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eleven strains of lactobacilli were tested for their ability to induce the murine macrophage-like cell line J774.1 to secrete cytokines. Some of the bacteria tested induce the production of interleukin(IL) 6, IL-12, and tumor necrosis factor alpha (TNF-alpha) by J774.1 cells. Seven strains also induced the production of IL-10. However, no IL-1beta was produced. Lactobacillus acidophilus TMC 0356 significantly induced the production of more IL-6, IL-10, IL-12, and TNF-alpha than the other bacteria tested (p < 0.0001; ANOVA). These results suggest that lactobacilli can activate macrophages to secrete both inflammatory and antiinflammatory cytokines. Selected strains might be used to bring about pro or antiinflammatory immune reactions.

引用

页码：1963 / 1966

页数：4

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