Protective effects of resveratrol and its analogues against free radical-induced oxidative hemolysis of red blood cells

被引：5

作者：

Fang, JG ^{[1
]}

Lu, M ^{[1
]}

Ma, LP ^{[1
]}

Yang, L ^{[1
]}

Wu, LM ^{[1
]}

Liu, ZL ^{[1
]}

机构：

[1] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2002年 / 20卷 / 11期

关键词：

peroxidation; antioxidation; resveratrol; red blood cell; hemolysis;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of resveratrol (3, 5, 4'-trihydroxy-trans-stilbene, 1) and its analogues, i.e., 4-hydroxy-trans-stilbene (2), 3, 5-dihydroxy-trans-stilbene (3), 3,4-dihydroxy-trans-stilbene (4), 4,4'-dihydroxy-trans-stilbene (5) and 2, 4, 4'-tribydroxy-trans-stilbene (6). The hemolysis of RBCs was induced by a water-soluble free radical initiator 2, 2'-azobis (2-amidinopropane hydrochloride) (AAPH). It was found that addition of AAPH at 37degreesC to the suspension of RBCs caused fast hemolysis after a short period of inhibition period, and addition of 1-6 significantly suppressed the hemolysis. Compound 4 winch bears an ortho-dihydroxyl functionality showed much more effective anti-hemolysis activity than that of resveratrol and the other analogues.

引用

页码：1313 / 1318

页数：6

共 42 条

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