The function of costimulatory molecules and the development of IL-4-producing T cells

被引：67

作者：

Gause, WC

Halvorson, MJ

Lu, P

Greenwald, R

Linsley, P

Urban, JF

Finkelman, FD

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DEPT CELLULAR IMMUNOL,SEATTLE,WA 98121

[2] USDA ARS,PARASITE IMMUNOBIOL LAB,BELTSVILLE,MD 20705

[3] UNIV CINCINNATI,COLL MED,DEPT MED,CINCINNATI,OH 45267

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(97)01005-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of IL-4-producing effector T cells during a type 2 immune response requires signaling through B7 ligands, but probably not CD40 ligands. Here, William Gause and colleagues review the still controversial role of CD28 and CTLA-4 on T cells, and B7-1 and B7-2 on antigen-presenting cells, and provide a model to incorporate recent findings.

引用

页码：115 / 120

页数：6

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