Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats

被引：61

作者：

Abrahám, CS

Harada, N

Deli, MA

Niwa, M

机构：

[1] Nagasaki Univ, Sch Med, Dept Pharmacol 1, Nagasaki 8528523, Japan

[2] Nagasaki Univ, Sch Med, Dept Anesthesiol, Nagasaki 852, Japan

[3] Hungarian Acad Sci, Biol Res Ctr, Inst Biophys, Mol Neurobiol Lab, H-6701 Szeged, Hungary

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2002年 / 22卷 / 04期

基金：

日本学术振兴会;

关键词：

blood-brain barrier permeability; cerebral ischemia-reperfusion; Evan's blue-albumin; sodium fluorescein; stroke-prone spontaneously hypertensive rat;

D O I：

10.1023/A:1021067822435

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. The aim of the present study was to reveal the effect of transient forebrain ischemia on the regional and temporal changes in the permeability of the blood-brain barrier (BBB) permeability for sodium fluorescein (MW: 376 Da) and Evan's blue-labeled albumin (MW: 67 kDa) in stroke-prone spontaneously hypertensive rats (SHRSP). 2. BBB permeability was significantly higher in the brain regions of 16-week-old control SHRSP than those in age-matched normotensive Wistar-Kyoto rats. 3. Transient forebrain ischemia evoked by 10-min bilateral carotid occlusion increased the permeability of the BBB for albumin, but not for sodium fluorescein, after 6 and 24 h of reperfusion in brain regions of SHRSP. 4. Extravasation of serum macromolecules may contribute to neuronal loss and development of hypertensive encephalopathy in SHRSP.

引用

页码：455 / 462

页数：8

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