Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone

被引:4
作者
Katayama, Y
Takimoto, H
Fujii, N
Kimura, G
Omoto, E
Harada, M
机构
[1] Second Dept. of Internal Medicine, Okayama University, Medical School, Okayama 700
关键词
trisomy; 8; MLL gene rearrangement; clonal evolution;
D O I
10.1038/sj.leu.2400708
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A 20-year-old Japanese man was referred because of severe pancytopenia with 14% of abnormal blasts in hypocellular bone marrow. After treatment by granulocyte colony-stimulating factor (G-CSF) and transfusions of red blood cells, spontaneous remission was subsequently achieved. After 3 months' remission, however, the patient developed AML characterized by the abnormal karyotype: 46XY,+8,t(9;11)(p22;q23). FISH study revealed the presence of trisomy 8 clone also in the hypoplastic state. While MLL-AF9 chimeric mRNA was observed in leukemic cells, it was not detectable in bone marrow cells from the hypoplastic state by RT-PCR. This is the first report of a trisomy 8 clone which evolved into one with a MLL gene rearrangement.
引用
收藏
页码:1380 / 1382
页数:3
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