Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone

被引：4

作者：

Katayama, Y

Takimoto, H

Fujii, N

Kimura, G

Omoto, E

Harada, M

机构：

[1] Second Dept. of Internal Medicine, Okayama University, Medical School, Okayama 700

来源：

LEUKEMIA | 1997年 / 11卷 / 08期

关键词：

trisomy; 8; MLL gene rearrangement; clonal evolution;

D O I：

10.1038/sj.leu.2400708

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 20-year-old Japanese man was referred because of severe pancytopenia with 14% of abnormal blasts in hypocellular bone marrow. After treatment by granulocyte colony-stimulating factor (G-CSF) and transfusions of red blood cells, spontaneous remission was subsequently achieved. After 3 months' remission, however, the patient developed AML characterized by the abnormal karyotype: 46XY,+8,t(9;11)(p22;q23). FISH study revealed the presence of trisomy 8 clone also in the hypoplastic state. While MLL-AF9 chimeric mRNA was observed in leukemic cells, it was not detectable in bone marrow cells from the hypoplastic state by RT-PCR. This is the first report of a trisomy 8 clone which evolved into one with a MLL gene rearrangement.

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页码：1380 / 1382

页数：3

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