Evidence for Camel-to-Human Transmission of MERS Coronavirus

被引：648

作者：

Azhar, Esam I. ^{[1
,2
]}

El-Kafrawy, Sherif A. ^{[2
]}

Farraj, Suha A. ^{[2
]}

Hassan, Ahmed M. ^{[2
]}

Al-Saeed, Muneera S. ^{[2
]}

Hashem, Anwar M. ^{[2
,3
]}

Madani, Tariq A. ^{[4
]}

机构：

[1] King Abdulaziz Univ, Dept Med Lab Technol, Fac Appl Med Sci, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, Special Infect Agents Unit, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia

[3] King Abdulaziz Univ, Fac Med, Dept Med Microbiol & Parasitol, Jeddah 21589, Saudi Arabia

[4] King Abdulaziz Univ, Fac Med, Dept Med, Jeddah 21589, Saudi Arabia

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2014年 / 370卷 / 26期

关键词：

RESPIRATORY SYNDROME CORONAVIRUS; MIDDLE-EAST; DROMEDARY CAMELS;

D O I：

10.1056/NEJMoa1401505

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were positive for MERS-CoV RNA. In addition, MERS-CoV was isolated from the patient and the camel. The full genome sequences of the two isolates were identical. Serologic data indicated that MERS-CoV was circulating in the camels but not in the patient before the human infection occurred. These data suggest that this fatal case of human MERS-CoV infection was transmitted through close contact with an infected camel.

引用

页码：2499 / 2505

页数：7

共 16 条

[1] [Anonymous], 2013, LAB TEST MIDDL E RES
[2] Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus
Assiri, Abdullah
McGeer, Allison
Perl, Trish M.
Price, Connie S.
Al Rabeeah, Abdullah A.
Cummings, Derek A. T.
Alabdullatif, Zaki N.
Assad, Maher
Almulhim, Abdulmohsen
Makhdoom, Hatem
Madani, Hossam
Alhakeem, Rafat
Al-Tawfiq, Jaffar A.
Cotten, Matthew
Watson, Simon J.
Kellam, Paul
Zumla, Alimuddin I.
Memish, Ziad A.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (05) : 407 - 416
[3] Bermingham A, 2012, EUROSURVEILLANCE, V17, P6
[4] Corman VM, 2012, EUROSURVEILLANCE, V17, P2
[5] Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study
Cotten, Matthew
Watson, Simon J.
Kellam, Paul
Al-Rabeeah, Abdullah A.
Makhdoom, Hatem Q.
Assiri, Abdullah
Al-Tawfiq, Jaffar A.
Alhakeem, Rafat F.
Madani, Hossam
AlRabiah, Fahad A.
Al Hajjar, Sami
Al-Nassir, Wafa N.
Albarrak, Ali
Flemban, Hesham
Balkhy, Hanan H.
Alsubaie, Sarah
Palser, Anne L.
Gall, Astrid
Bashford-Rogers, Rachael
Rambaut, Andrew
Zumla, Alimuddin I.
Memish, Ziad A.
[J]. LANCET, 2013, 382 (9909) : 1993 - 2002
[6] Guery B, 2013, LANCET, V381, P2254
[7] Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission
Guery, Benoit
Poissy, Julien
el Mansouf, Loubna
Sejourne, Caroline
Ettahar, Nicolas
Lemaire, Xavier
Vuotto, Fanny
Goffard, Anne
Behillil, Sylvie
Enouf, Vincent
Caro, Valerie
Mailles, Alexandra
Che, Didier
Manuguerra, Jean-Claude
Mathieu, Daniel
Fontanet, Arnaud
van der Werf, Sylvie
[J]. LANCET, 2013, 381 (9885) : 2265 - 2272
[8] Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation
Haagmans, Bart L.
Al Dhahiry, Said H. S.
Reusken, Chantal B. E. M.
Raj, V. Stalin
Galiano, Monica
Myers, Richard
Godeke, Gert-Jan
Jonges, Marcel
Farag, Elmoubasher
Diab, Ayman
Ghobashy, Hazem
Alhajri, Farhoud
Al-Thani, Mohamed
Al-Marri, Salih A.
Al Romaihi, Hamad E.
Al Khal, Abdullatif
Bermingham, Alison
Osterhaus, Albert D. M. E.
AlHajri, Mohd M.
Koopmans, Marion P. G.
[J]. LANCET INFECTIOUS DISEASES, 2014, 14 (02) : 140 - 145
[9] Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa
Ithete, Ndapewa Laudika
Stoffberg, Samantha
Corman, Victor Max
Cottontail, Veronika M.
Richards, Leigh Rosanne
Schoeman, M. Corrie
Drosten, Christian
Drexler, Jan Felix
Preiser, Wolfgang
[J]. EMERGING INFECTIOUS DISEASES, 2013, 19 (10) : 1697 - 1699
[10] Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia
Memish, Ziad A.
Mishra, Nischay
Olival, Kevin J.
Fagbo, Shamsudeen F.
Kapoor, Vishal
Epstein, Jonathan H.
AlHakeem, Rafat
Al Asmari, Mushabab
Islam, Ariful
Kapoor, Amit
Briese, Thomas
Daszak, Peter
Al Rabeeah, Abdullah A.
Lipkin, W. Ian
[J]. EMERGING INFECTIOUS DISEASES, 2013, 19 (11) : 1819 - 1823

← 1 2 →