Effect of thyroid hormone administration on estrogen-induced sex behavior in female mice

被引：32

作者：

Morgan, MA

Dellovade, TL

Pfaff, DW

机构：

[1] Rockefeller Univ, Neurobiol & Behav Lab, New York, NY 10021 USA

[2] Eunice Kennedy Shriver Ctr Mental Retardat Inc, Dept Biomed Sci, Waltham, MA USA

来源：

HORMONES AND BEHAVIOR | 2000年 / 37卷 / 01期

关键词：

thyroid hormone; estrogen; mice; lordosis;

D O I：

10.1006/hbeh.1999.1553

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Effects of thyroid hormones on reproductive processes have been described in sheep, birds, and rats. To extend this subject to mice for eventual analysis with genetically modified animals, we looked for effects of thyroid hormone treatment on lordosis behavior of ovariectomized estrogen-treated female mice. High doses of thyroid hormones reduced lordosis behavior. Since we could not explain this result by pharmacokinetic or peripheral effects, we infer that it worked by a central mechanism. Future investigations must determine whether endogenous fluctuations within the thyroid's normal physiological range have any behavioral effects. (C) 2000 Academic Press.

引用

页码：15 / 22

页数：8

共 16 条

[1] Photorefractoriness in European starlings (Sturnus vulgaris) is not dependent upon the long-day-induced rise in plasma thyroxine [J].