An efficient synthetic route to 2-(1,2-dithiolan-3-yl)acetic acid. Trisnorlipoic acid and amide derivatives.

被引：8

作者：

Chen, YS ^{[1
]}

Lawton, RG ^{[1
]}

机构：

[1] UNIV MICHIGAN, DEPT CHEM, ANN ARBOR, MI 48109 USA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(97)01319-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A simple, efficient synthesis of 2-(1,2-dithiolan-3-yl)acetic acid from Meldrum's acid, acrolein and thioacetic acid is described. The isopropyldene 2,4-bis(acetylthio)butane-1,1-dicarboxyl formed in the three-component, single container process, can be methanolized to the corresponding dimethyl ester and then hydrolyzed, oxidized to the disulfide and decarboxylated to 2-(1,2-dithiolan-3-yl)acetic acid. ?he acid can be converted by conventional reagents into a variety of amide derivatives. (C) 1997 Elsevier Science Ltd.

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页码：5785 / 5788

页数：4

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