Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization

被引:219
作者
Hamelmann, E
Oshiba, A
Loader, J
Larsen, GL
Gleich, G
Lee, J
Gelfand, EW
机构
[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DIV BASIC SCI,DENVER,CO 80206
[2] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DIV PULM MED,DENVER,CO 80206
[3] MAYO CLIN,ROCHESTER,MN
[4] MAYO CLIN,SCOTTSDALE,AZ
关键词
D O I
10.1164/ajrccm.155.3.9117011
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Eosinophils play a central role in the inflammatory response associated with bronchial asthma. We studied the involvement of eosinophils in the development of airway hyperresponsiveness (AHR) in a mouse model of allergic airway sensitization. Sensitization of BALB/c mice to OVA via the airways induced allergen-specific T-cell responses, IgE production, immediate cutaneous hypersensitivity (ICH), and increased airway reactivity. Airway sensitization was associated with eosinophil infiltration of the airways and increased production of interleukin-5 (IL-5) in cultures of peribronchial lymph node cells. Treatment of OVA-challenged animals with anti-IL-5 antibody during the sensitization protocol completely abolished the infiltration of eosinophils into the lung tissue and prevented the development of AHR without affecting levels of allergen-specific IgE, cutaneous hypersensitivity and allergen-specific T cell responses. These findings demonstrate that infiltration of lung tissue by eosinophils, triggered by increased IL-5 production, is a major factor in the development of AHR in this mouse model of airway sensitization.
引用
收藏
页码:819 / 825
页数:7
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