Apototic cell-derived membrane vesicles induce CD83 expression on human mdDC

被引：5

作者：

Fehr, Eva-Marie ^{[1
]}

Kierschke, Sonja ^{[1
]}

Max, Regina ^{[1
]}

Gerber, Alexander ^{[2
]}

Lorenz, Hanns-Martin ^{[1
]}

Schiller, Martin ^{[1
]}

机构：

[1] Univ Heidelberg, Dept Med 5, D-69120 Heidelberg, Germany

[2] Acad Teaching Hosp, Charite, HELIOS Clin Emil von Behring, D-14165 Berlin, Germany

来源：

AUTOIMMUNITY | 2009年 / 42卷 / 04期

关键词：

Apo; SLE; apototic cell-derived membrane vesicles; inflammation; SYSTEMIC-LUPUS-ERYTHEMATOSUS; APOPTOTIC CELLS; DENDRITIC CELLS; MACROPHAGES; CLEARANCE; BODIES; ALPHA;

D O I：

10.1080/08916930902832173

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A characteristic of apo cell death is the shedding of membrane vesicles from the dying cell. This process is also referred to as apo membrane blebbing. These apo particles contain various autoantigens and are effectively engulfed by phagocytes. A defective phagocytosis has been described in autoimmune diseases like systemic lupus erythematosus and this defect might lead to an accumulation of apo cells and bodies. Thus, we investigated the interactions between apototic cell-derived membrane vesicles (ACdMV), and myeloid dendritic cell (DC). ACdMV were isolated from the supernatant of apo lymphocytes. These isolated ACdMV were morphologically characterized as membrane coated vesicles of an average size of 500 nm. Coincubating isolated ACdMV with iDC we observed CD83 surface expression of the latter. Accumulation of ACdMV may contribute to an inflammatory immune response in autoimmune diseases.

引用

页码：322 / 324

页数：3

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