IL-17 potentiates neuronal injury induced by oxygen-glucose deprivation and affects neuronal IL-17 receptor expression

被引：67

作者：

Wang, Dan-dan ^{[1
]}

Zhao, Yan-feng ^{[2
]}

Wang, Guang-you ^{[1
]}

Sun, Bo ^{[1
]}

Kong, Qing-fei ^{[1
]}

Zhao, Kai ^{[1
]}

Zhang, Yao ^{[1
]}

Wang, Jing-hua ^{[1
]}

Liu, Yu-mei ^{[1
]}

Mu, Li-li ^{[1
]}

Wang, De-sheng ^{[2
]}

Li, Hu-lun ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Neurobiol, Heilongjiang Prov Key Lab Neurobiol, Harbin 150081, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 1, Dept Neurol, Harbin 150081, Heilongjiang, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 212卷 / 1-2期

关键词：

Interlukin-17 (IL-17); IL-17 receptor (IL-17R); Oxygen-glucose deprivation (OGD); Ischemia; MESSENGER-RNA EXPRESSION; BLOOD MONONUCLEAR-CELLS; INTERLEUKIN-17; FAMILY; MULTIPLE-SCLEROSIS; CEREBRAL-ISCHEMIA; STROKE; INFLAMMATION; RAT; CYTOKINES; SYSTEM;

D O I：

10.1016/j.jneuroim.2009.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interlukin-17 (IL-17) is active in a variety of brain injuries, including ischemia. The objective of this study was to test the hypothesis that IL-17 potentiates neuronal injury after stroke. increased expression of IL-17 and IL-17 receptor (IL-17R) in serum and cortex was evaluated by ELISA, RT-PCR and immunohistochemistry. In the in vitro model of oxygen-glucose deprivation (OGD), IL-17 showed a dose-dependent effect in promoting neuronal injury through IL-17-IL-17R combination which can be blocked by IL-17R/Fc chimera. Our results demonstrated the up-regulation of IL-17 and IL-17R following permanent middle cerebral artery occlusion and suggested that they contributed to stroke outcome. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：17 / 25

页数：9

共 39 条

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