Membrane phospholipid alterations in Alzheimer's disease: Deficiency of ethanolamine plasmalogens

被引：139

作者：

Farooqui, AA ^{[1
]}

Rapoport, SI ^{[1
]}

Horrocks, LA ^{[1
]}

机构：

[1] NIA, NEUROSCI LAB, BETHESDA, MD 20892 USA

来源：

NEUROCHEMICAL RESEARCH | 1997年 / 22卷 / 04期

关键词：

plasmalogens; phospholipase A(2); lipid peroxidation; plasma membrane; signal transduction; neurodegradation; Alzheimer's disease;

D O I：

10.1023/A:1027380331807

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ethanolamine plasmalogens are decreased whereas serine glycerophospholipids are significantly increased in plasma membrane phospholipid in affected regions of brain in Alzheimer's disease. This may be due to stimulation of Ca2+-independent plasmalogen-selective phospholipase A(2), which was recently discovered in brain. This phospholipase A(2) differs from other Ca2+-independent phospholipases A(2) in response to ATP and various inhibitors. It may be responsible for excess release of arachidonic acid and accumulation of prostaglandins and lipid peroxides in AD. Accumulation of the above lipid metabolites due to abnormal receptor function and signal transduction may contribute to neurodegeneration in AD.

引用

页码：523 / 527

页数：5

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