A new SIV co-receptor, STRL33

被引：118

作者：

Alkhatib, G

Liao, F

Berger, EA

Farber, JM

Peden, KWC

机构：

[1] NIAID,CLIN INVEST LAB,NIH,BETHESDA,MD 20892

[2] US FDA,CTR BIOL EVALUAT & RES,RETROVIRUS RES LAB,BETHESDA,MD 20892

来源：

NATURE | 1997年 / 388卷 / 6639期

关键词：

D O I：

10.1038/40789

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The identification last year of chemokine receptors as fusion co-factors for HIV-11,2,3,4,5,6 has contributed significantly towards understanding HIV transmission and AIDS pathogenesis (see ref. 7 for a review). Because the experimental infection of rhesus macaques with simian immunodeficiency virus (SIV) and the resulting development of an AIDS-like illness is the best animal model for HIV disease in humans8, identifying SIV co-receptors analogous to those used by HIV has obvious importance. We now report that STRL33, a chemokine receptor-like orphan receptor expressed in activated human lymphocytes and acting as a fusion co-factor with envelope glycoproteins (Envs) from HIV-1 strains of diverse tropisms9, is a co-receptor for SIV.

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页码：238 / 238

页数：1

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