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TGF-β in blood:: a complex problem

被引：173
作者：
Grainger, DJ
Mosedale, DE
Metcalfe, JC
机构：
[1] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England
[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2000年 / 11卷 / 1-2期
关键词：
TGF-beta; plasma; ELISA; wound healing; blood clot;
D O I：
10.1016/S1359-6101(99)00037-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cytokine transforming growth factor-beta (TGF-beta) was initially purified from human platelets, a rich source of this protein. In addition to platelets, TGF-beta 1 is also found in other blood fractions, including plasma and the circulating leukocytes. However, more than 15 years after the initial isolation of TGF-beta 1, there remains no consensus on how much TGF-beta 1 is present in normal human plasma. Here we review the difficulties associated with measuring TGF-beta concentrations in complex biological fluids, and discuss the current state of knowledge on the distribution of TGF-beta isoforms in various blood fractions as well as the nature of the TGF-beta-containing protein complexes. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：133 / 145
页数：13
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