Toxin A-negative, toxin B-positive Clostridium difficile

被引：145

作者：

Drudy, Denise ^{[1
]}

Fanning, Seamus

Kyne, Lorraine

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Ctr Food Safety, Sch Agr Food Sci & Vet Med, Dublin 4, Ireland

[2] Mater Misericordiae Univ Hosp, Dept Med Older Person, Dublin 7, Ireland

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2007年 / 11卷 / 01期

关键词：

A(-)B(+) clostridium difficile; infectious diarrhea; bacterial genotyping;

D O I：

10.1016/j.ijid.2006.04.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clostridium difficile is a major cause of infectious diarrhea in hospitalized patients. Many pathogenic strains of Clostridium difficile produce two toxins TcdA and TcdB, both of which are pro-inflammatory and enterotoxic in human intestine. Clinically relevant toxin A-negative, toxin B-positive (A(-)B(+)) strains of Clostridium difficile that cause diarrhea and colitis in humans have been isolated with increasing frequency worldwide. This perspective describes these important toxin variant strains and highlights the need to use Clostridium difficile diagnostic methods that can detect both TcdA and TcdB. (c) 2006 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

收藏

页码：5 / 10

页数：6

相关论文

共 54 条

[1]

al-Barrak A, 1999, Can Commun Dis Rep, V25, P65

[2] Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea [J].

Alfa, MJ ;

Kabani, A ;

Lyerly, D ;

Moncrief, S ;

Neville, LM ;

Al-Barrak, A ;

Harding, GKH ;

Dyck, B ;

Olekson, K ;

Embil, JM .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (07) :2706-2714

[3] Secular trends in hospital-acquired Clostridium difficile disease in the United States, 1987-2001 [J].

Archibald, LK ;

Banerjee, SN ;

Jarvis, WR .

JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (09) :1585-1589

[4] A European survey of diagnostic methods and testing protocols for Clostridium difficile [J].

Barbut, F ;

Delmée, M ;

Brazier, JS ;

Petit, JC ;

Poxton, IR ;

Rupnik, M ;

Lalande, V ;

Schneider, C ;

Mastrantonio, P ;

Alonso, R ;

Kuipjer, E ;

Tvede, M .

CLINICAL MICROBIOLOGY AND INFECTION, 2003, 9 (10) :989-996

[5] Prevalence and genetic characterization of toxin A variant strains of Clostridium difficile among adults and children with diarrhea in France [J].

Barbut, F ;

Lalande, V ;

Burghoffer, B ;

Thien, HV ;

Grimprel, E ;

Petit, JC .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (06) :2079-2083

[6] Antibiotic-associated diarrhea [J].

Bartlett, JG .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (05) :334-339

[7] MOLECULAR, IMMUNOLOGICAL, AND BIOLOGICAL CHARACTERIZATION OF A TOXIN-A-NEGATIVE, TOXIN-B-POSITIVE STRAIN OF CLOSTRIDIUM-DIFFICILE [J].

BORRIELLO, SP ;

WREN, BW ;

HYDE, S ;

SEDDON, SV ;

SIBBONS, P ;

KRISHNA, MM ;

TABAQCHALI, S ;

MANEK, S ;

PRICE, AB .

INFECTION AND IMMUNITY, 1992, 60 (10) :4192-4199

[8]

Brazier JS, 1999, J HOSP INFECT, V42, P248

[9] A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxins [J].

Chaves-Olarte, E ;

Löw, P ;

Freer, E ;

Norlin, T ;

Weidmann, M ;

von Eichel-Streiber, C ;

Thelestam, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :11046-11052

[10] DEVELOPMENT OF A RAPID AND EFFICIENT RESTRICTION-ENDONUCLEASE ANALYSIS TYPING SYSTEM FOR CLOSTRIDIUM-DIFFICILE AND CORRELATION WITH OTHER TYPING SYSTEMS [J].

CLABOTS, CR ;

JOHNSON, S ;

BETTIN, KM ;

MATHIE, PA ;

MULLIGAN, ME ;

SCHABERG, DR ;

PETERSON, LR ;

GERDING, DN .

JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (07) :1870-1875

← 1 2 3 4 5 6 →