Plasma-Advanced Oxidation Protein Products Are Potent High-Density Lipoprotein Receptor Antagonists In Vivo

被引:89
作者
Marsche, Gunther [1 ]
Frank, Sasa [2 ]
Hrzenjak, Andelko [3 ]
Holzer, Michael
Dirnberger, Sabine
Wadsack, Christian [4 ]
Scharnagl, Hubert [5 ,6 ]
Stojakovic, Tatjana [5 ,6 ]
Heinemann, Akos
Oettl, Karl [7 ]
机构
[1] Med Univ Graz, Ctr Theoret Clin Med 2, Inst Expt & Clin Pharmacol, A-8010 Graz, Austria
[2] Med Univ Graz, Inst Mol Biol & Biochem, A-8010 Graz, Austria
[3] Med Univ Graz, Dept Pathol, A-8010 Graz, Austria
[4] Med Univ Graz, Clin Obstet & Gynecol, A-8010 Graz, Austria
[5] Med Univ Graz, Inst Clin Med, A-8010 Graz, Austria
[6] Med Univ Graz, Chem Lab Diagnost, A-8010 Graz, Austria
[7] Med Univ Graz, Inst Physiol Chem, A-8010 Graz, Austria
基金
奥地利科学基金会;
关键词
AOPP; hemodialysis; myeloperoxidase; oxidative stress; HDL; REVERSE CHOLESTEROL TRANSPORT; GLYCATION END-PRODUCTS; CHRONIC-RENAL-FAILURE; SCAVENGER RECEPTOR; CLASS-B; SR-BI; STRESS; RAGE; ATHEROSCLEROSIS; HEMODIALYSIS;
D O I
10.1161/CIRCRESAHA.108.193169
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Advanced oxidation protein products (AOPPs) are carried by oxidized plasma proteins, especially albumin and accumulate in subjects with renal disease and coronary artery disease. AOPPs represent an excellent novel marker of oxidative stress and their roles in the development of cardiovascular disease might be of great importance. Here, we show that in vitro-generated AOPP-albumin binds with high affinity to the high-density lipoprotein (HDL) receptor scavenger receptor class B type I (SR-BI). Already an equimolar concentration of AOPP-albumin to HDL blocked HDL association to SR-BI and effectively inhibited SR-BI-mediated cholesterol ester (CE) uptake. Interestingly, albumin extensively modified by advanced glycation end products (AGE-albumin), which is an established SR-BI ligand known to accumulate in renal disease, only weakly interfered with HDL binding to SR-BI. Furthermore, AOPP-albumin administration increased the plasma half-life of [H-3]CE-HDL in control mice 1.6-fold (P=0.01) and 8-fold (P=0.0003) in mice infected with adenoviral vectors encoding human SR-BI. Moreover, albumin isolated from hemodialysis patients, but not albumin isolated from healthy controls, markedly inhibited SR-BI-mediated HDL-CE transfer in vitro dependent on the AOPP content of albumin. These results indicate that AOPP-albumin effectively blocks SR-BI in vitro and in vivo. Thus, depressed plasma clearance of HDL-cholesterol may contribute to the abnormal composition of HDL and the high cardiovascular risk observed in patients with chronic renal failure. (Circ Res. 2009; 104: 750-757.)
引用
收藏
页码:750 / 757
页数:8
相关论文
共 32 条
  • [1] Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    Acton, S
    Rigotti, A
    Landschulz, KT
    Xu, SZ
    Hobbs, HH
    Krieger, M
    [J]. SCIENCE, 1996, 271 (5248) : 518 - 520
  • [2] Modification of the oxidative stress biomarker AOPP assay: Application in uremic samples
    Anderstam, Bjorn
    Ann-Christin, Bragfors-Helin
    Valli, Alessandro
    Stenvinkel, Peter
    Lindholm, Bengt
    Suliman, Mohamed E.
    [J]. CLINICA CHIMICA ACTA, 2008, 393 (02) : 114 - 118
  • [3] Biochemical and spectrophotometric significance of advanced oxidized protein products
    Capeillère-Blandin, C
    Gausson, V
    Descamps-Latscha, B
    Witko-Sarsat, V
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2004, 1689 (02): : 91 - 102
  • [4] Respective role of uraemic toxins and myeloperoxidase in the uraemic state
    Capeillere-Blandin, Chantal
    Gausson, Valerie
    Nguyen, Anh Thu
    Descamps-Latscha, Beatrice
    Drueke, Tilman
    Witko-Sarsat, Veronique
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (06) : 1555 - 1563
  • [5] Descamps-Latscha A, 2005, AM J KIDNEY DIS, V45, P39, DOI 10.1053/j.ajkd.2004.09.011
  • [6] EFFECT OF CHRONIC-RENAL-FAILURE ON HIGH-DENSITY-LIPOPROTEIN KINETICS
    FUH, MMT
    LEE, CM
    JENG, CY
    SHEN, DC
    SHIEH, SM
    REAVEN, GM
    CHEN, YDI
    [J]. KIDNEY INTERNATIONAL, 1990, 37 (05) : 1295 - 1300
  • [7] Advanced oxidation protein products activate vascular endothelial cells via a RAGE-mediated signaling pathway
    Guo, Zhi Jian
    Niu, Hong Xin
    Hou, Fan Fan
    Zhang, Lu
    Fu, Ning
    Nagai, Ryoji
    Lu, Xiao
    Chen, Bai Hong
    Shan, Yue Xin
    Tian, Jian Wei
    Nagaraj, Ram H.
    Xie, Di
    Zhang, Xun
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2008, 10 (10) : 1699 - 1712
  • [8] Albumin is the major plasma protein target of oxidant stress in uremia
    Himmelfarb, J
    McMonagle, E
    [J]. KIDNEY INTERNATIONAL, 2001, 60 (01) : 358 - 363
  • [9] CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products
    Iwao, Yasunori
    Nakajou, Keisuke
    Nagai, Ryoji
    Kitamura, Kenichiro
    Anraku, Makoto
    Maruyama, Toru
    Otagiri, Masaki
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 295 (06) : F1871 - F1880
  • [10] HDL-inflammatory index correlates with poor outcome in hemodialysis patients
    Kalantar-Zadeh, K.
    Kopple, J. D.
    Kamranpour, N.
    Fogelman, A. M.
    Navab, M.
    [J]. KIDNEY INTERNATIONAL, 2007, 72 (09) : 1149 - 1156