A novel simple in situ biomimetic and simultaneous deposition of bonelike apatite within biopolymer matrix as bone graft substitutes

被引：14

作者：

Abdal-hay, Abdalla ^{[1
]}

Hamdy, Abdel Salam ^{[2
]}

Khalil, Khalil Abdelrazek ^{[3
,4
]}

Lim, Ju Hyun ^{[5
]}

机构：

[1] South Valley Univ, Fac Engn, Dept Engn Mat & Mech Design, Qena, Egypt

[2] Univ Texas Pan Amer, Coll Engn & Comp Sci, Dept Mfg Engn, Edinburg, TX 78541 USA

[3] King Saud Univ, Coll Engn, Dept Mech Engn, Riyadh 11421, Saudi Arabia

[4] Aswan Univ, Fac Energy Engn, Dept Mech Engn, Aswan, Egypt

[5] Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Urol, Kangnung, South Korea

来源：

MATERIALS LETTERS | 2014年 / 137卷

关键词：

Bone tissue engineering; Nanocomposite; Biocompatibility; Biomaterials; Bone graft substitutes; CHITOSAN; NANOFIBERS; SCAFFOLDS; MEMBRANE;

D O I：

10.1016/j.matlet.2014.09.038

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

A novel simple in situ biomimetic strategy used for the first time for rapid induction of bonelike apatite nanosized into the chitosan (as) matrix. The precipitated particles from the surrounding simulated body fluid within polymer matrix during the hydrothermal process showed a uniform distribution and perfect matching with bonelike minerals. The excellent bone-bonding property and biocompatibility of bonelike apatite could provide a suitable environment for the attachment and ingrowth of MC3T3-E1 osteoblasts. The bioactive apatite film designed in this article can make the novel bonelike apatite/ CIS matrix nanocomposite as attractive substitutes for bone graft and regeneration. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：260 / 264

页数：5

共 14 条

[1]

In vitro bioactivity of implantable Ti materials coated with PVAc membrane layer [J].