Induction of transforming growth factor-β1 production in human cells by herpes simplex virus

被引:24
作者
Méndez-Samperio, P [1 ]
Hernandez, M [1 ]
Ayala, HE [1 ]
机构
[1] IPN, Escuela Nacl Ciencias Biol, Dept Inmunol, Mexico City 11340, DF, Mexico
关键词
D O I
10.1089/107999000312405
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transforming growth factor-beta (TGF-beta) is a cytokine of particular interest in human retrovirus infections because it can abrogate antigen-specific cellular activation. Although TGF-beta production has been observed in HIV infections, there is no evidence that herpes simplex virus (HSV)-stimulated human cells produce this cytokine, Here were present evidence, for the first time, that in vitro infection of human mononuclear cells with HSV type 1 (HSV-1) induced the release of TGF-beta 1 protein. The production of this cytokine was time dependent and was found highly significant (p < 0.001) after 48 h, In addition, me observed that the secretion of TGF-beta 1 was dependent on the concentration of human cells. It was found that virus needs to replicate in human cells for the production of TGF-beta 1, as UV-inactivated virus did not induce significant production of cytokine protein. Interestingly, increased HSV-1-induced TGF-beta 1 production in cultures containing antiinterleukin (IL)-12 or antiinterferon (IFN)-gamma antibodies was observed, whereas an irrelevant antibody had no effect on the production of this cytokine, Taken together, these findings indicate that human cells synthetize TGF-beta 1 in response to HSV-1 and at the same time suggest that HSV-1-induced TGF-beta 1 production mag be one of the mechanisms by which HSV can at least partly evade activation of the host immune system.
引用
收藏
页码:273 / 280
页数:8
相关论文
共 36 条
[1]   EXPRESSION AND SECRETION OF TYPE-BETA TRANSFORMING GROWTH-FACTOR BY ACTIVATED HUMAN MACROPHAGES [J].
ASSOIAN, RK ;
FLEURDELYS, BE ;
STEVENSON, HC ;
MILLER, PJ ;
MADTES, DK ;
RAINES, EW ;
ROSS, R ;
SPORN, MB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (17) :6020-6024
[2]   TRANSFORMING GROWTH-FACTOR-BETA IN LEISHMANIAL INFECTION - A PARASITE ESCAPE MECHANISM [J].
BARRALNETTO, M ;
BARRAL, A ;
BROWNELL, CE ;
SKEIKY, YAW ;
ELLINGSWORTH, LR ;
TWARDZIK, DR ;
REED, SG .
SCIENCE, 1992, 257 (5069) :545-548
[3]   RECOMBINANT GAMMA INTERFERON DIFFERENTIALLY REGULATES CLASS-II ANTIGEN EXPRESSION AND BIOSYNTHESIS ON CULTURED NORMAL HUMAN KERATINOCYTES [J].
BASHAM, TY ;
NICKOLOFF, BJ ;
MERIGAN, TC ;
MORHENN, VB .
JOURNAL OF INTERFERON RESEARCH, 1985, 5 (01) :23-32
[4]   NOVEL FEATURES OF THE RESPIRATORY-TRACT T-CELL RESPONSE TO INFLUENZA-VIRUS INFECTION - LUNG T-CELLS INCREASE EXPRESSION OF GAMMA-INTERFERON MESSENGER-RNA IN-VIVO AND MAINTAIN HIGH-LEVELS OF MESSENGER-RNA EXPRESSION FOR INTERLEUKIN-5 (IL-5) AND IL-10 [J].
BAUMGARTH, N ;
BROWN, L ;
JACKSON, D ;
KELSO, A .
JOURNAL OF VIROLOGY, 1994, 68 (11) :7575-7581
[5]  
CUNNINGHAM AL, 1984, J IMMUNOL, V132, P197
[6]  
CZARNIECKI CW, 1988, J IMMUNOL, V140, P4217
[7]   TRANSFORMING GROWTH-FACTOR-BETA INHIBITS INTERLEUKIN-12-INDUCED PRODUCTION OF INTERFERON-GAMMA BY NATURAL-KILLER-CELLS - A ROLE FOR TRANSFORMING GROWTH-FACTOR-BETA IN THE REGULATION OF T-CELL-INDEPENDENT RESISTANCE TO TOXOPLASMA-GONDII [J].
HUNTER, CA ;
BERMUDEZ, L ;
BEERNINK, H ;
WAEGELL, W ;
REMINGTON, JS .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (04) :994-1000
[8]   Acute encephalitis [J].
Johnson, RT .
CLINICAL INFECTIOUS DISEASES, 1996, 23 (02) :219-224
[9]   HSV-1-mediated modulation of cytokine gene expression in a permissive cell line: Selective upregulation [J].
Kanangat, S ;
Babu, JS ;
Knipe, DM ;
Rouse, BT .
VIROLOGY, 1996, 219 (01) :295-300
[10]   EXPRESSION OF CYTOKINE MESSENGER-RNA IN MURINE SPLENIC DENDRITIC CELLS AND BETTER INDUCTION OF T-CELL-DERIVED CYTOKINES BY DENDRITIC CELLS THAN BY MACROPHAGES DURING IN-VITRO COSTIMULATION ASSAY USING SPECIFIC ANTIGENS [J].
KANANGAT, S ;
NAIR, S ;
BABU, JS ;
ROUSE, BT .
JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 57 (02) :310-316