Artificial chromosomes: ideal vectors?

被引：27

作者：

Brown, WRA ^{[1
]}

Mee, PJ

Shen, MH

机构：

[1] Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2UH, England

[2] Univ Edinburgh, Ctr Genome Res, Edinburgh EH9 3JQ, Midlothian, Scotland

[3] Univ Oxford, Dept Biochem, Canc Res Campaign Chromosome Mol Biol Grp, Oxford OX1 3QU, England

来源：

TRENDS IN BIOTECHNOLOGY | 2000年 / 18卷 / 05期

关键词：

D O I：

10.1016/S0167-7799(00)01438-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Artificial chromosomes are DNA molecules of predictable structure, which are assembled in vitro from defined constituents that behave with the properties of natural chromosomes. Artificial chromosomes were first assembled in budding yeast and have since been useful in many aspects of yeast genetics. Several attempts have been made at building artificial chromosomes in mammals, although these have been met with limited success. Consequently, mini-chromosomes of defined structure have been developed to address questions regarding mammalian chromosome function and for biotechnological applications. Here we review progress in these areas and consider how it influences plans to build artificial chromosomes in plants and parasites.

引用

页码：218 / 223

页数：8

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