Anthrax: From antiquity and obscurity to a front-runner in bioterrorism

被引：14

作者：

Kyriacou, Demetrios N.

Adamski, Alys

Khardori, Nancy

机构：

[1] So Illinois Univ, Sch Med, Dept Internal Med, Div Infect Dis, Springfield, IL 62794 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Emergency Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2006年 / 20卷 / 02期

关键词：

D O I：

10.1016/j.idc.2006.03.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anthrax infection is caused by Bacillus anthracis, a large gram-positive, rod-shaped bacterium found in soil around the world. Although anthrax is usually a disease of grazing animals, human contact with animal products, such as hides, hairs, and wool that are contaminated with anthrax endospores can result in clinical infection with cutaneous, inhalational, gastrointestinal, and neurologic manifestations. Anthrax has recently become a front-runner in potential bioterrorism weapons. This article presents a brief history of anthrax, discusses different clinical presentations of anthrax, reviews the clinical characteristics that can be used to recognize inhalational anthrax victims, discusses current diagnostic and treatment modalities, and provides an overview of emerging and investigational therapies and vaccines.

引用

页码：227 / +

页数：26

共 115 条

[1] PATHOLOGY OF INHALATIONAL ANTHRAX IN 42 CASES FROM THE SVERDLOVSK OUTBREAK OF 1979 [J].

ABRAMOVA, FA ;

GRINBERG, LM ;

YAMPOLSKAYA, OV ;

WALKER, DH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2291-2294

[2] Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin [J].

Agrawal, A ;

Lingappa, J ;

Leppla, SH ;

Agrawal, S ;

Jabbar, A ;

Quinn, C ;

Pulendran, B .

NATURE, 2003, 424 (6946) :329-334

[3] PATHOGENESIS OF INHALATION ANTHRAX [J].

ALBRINK, WS .

BACTERIOLOGICAL REVIEWS, 1961, 25 (03) :268-&

[4]

*AM AC DERM, ANTHRAX

[5]

[Anonymous], 1881, 10 ANN REPORT LOCAL

[6]

Anonymous, 2001, MMWR Morb Mortal Wkly Rep, V50, P909

[7] No evidence of a mild form of inhalational Bacillus anthracis infection during a bioterrorism-related inhalational anthrax outbreak in Washington, DC, in 2001 [J].

Baggett, HC ;

Rhodes, JC ;

Fridkin, SK ;

Quinn, CP ;

Hageman, JC ;

Friedman, CR ;

Dykewicz, CA ;

Semenova, VA ;

Romero-Steiner, S ;

Elie, CM ;

Jernigan, JA .

CLINICAL INFECTIOUS DISEASES, 2005, 41 (07) :991-997

[8] Fatal inhalational anthrax in a 94-year-old Connecticut woman [J].

Barakat, LA ;

Quentzel, HL ;

Jernigan, JA ;

Kirschke, DL ;

Griffith, K ;

Spear, SM ;

Kelley, K ;

Barden, D ;

Mayo, D ;

Stephens, DS ;

Popovic, T ;

Marston, C ;

Zaki, SR ;

Guarner, J ;

Shieh, WJ ;

Carver, HW ;

Meyer, RF ;

Swerdlow, DL ;

Mast, EE ;

Hadler, JL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (07) :863-868

[9] Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization [J].

Beauregard, KE ;

Collier, RJ ;

Swanson, JA .

CELLULAR MICROBIOLOGY, 2000, 2 (03) :251-258

[10]

Bell H., 1924, J MISSOURI STATE MED, V21, P407

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