Sex differences in minocycline-induced neuroprotection after experimental stroke

被引：89

作者：

Li, Jun ^{[1
]}

McCullough, Louise D. ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Neurol, Farmington, CT 06030 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2009年 / 29卷 / 04期

关键词：

middle cerebral artery occlusion (MCAO); minocycline; poly(ADP-ribose) polymerase (PARP); sex differences; CELL-DEATH; CEREBRAL-ISCHEMIA; GENE DISRUPTION; POLYMERASE-1; INFLAMMATION; PROTECTS; TRIAL;

D O I：

10.1038/jcbfm.2009.3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Minocycline is neuroprotective in clinical and experimental stroke studies, due in part to its ability to inhibit poly (ADP-ribose) polymerase. Previous preclinical data have shown that interference with poly (ADP-ribose) polymerase signaling leads to sex-specific neuroprotection, reducing stroke injury only in males. In this study, we show that minocycline is ineffective at reducing ischemic damage in females after middle cerebral artery occlusion, likely due to effects on poly (ADP-ribose) polymerase signaling. Clinical trials must consider possible sex differences in the response to neuroprotective agents, if we hope to translate promising therapies to stroke patients of both sexes. Journal of Cerebral Blood Flow & Metabolism ( 2009) 29, 670-674; doi:10.1038/jcbfm.2009.3; published online 4 February 2009

引用

页码：670 / 674

页数：5

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