Maternal virus load during pregnancy and mother-to-child transmission of human immunodeficiency virus type 1: The French Perinatal Cohort studies

被引：115

作者：

Mayaux, MJ

Dussaix, E

Isopet, J

Rekacewicz, C

Mandelbrot, L

CiraruVigneron, N

Allemon, MC

Chambrin, V

Katlama, C

Delfraissy, JF

Puel, J

机构：

[1] SEROGEST Cohort and U. 292 INSERM, Hôpital Kremlin Bicêtre

[2] Hôpital Bicêtre, INSERAI Unité 292, Secteur Bleu Pierre Marie, 94276 Le Kremlin Bicêtre Cedex, 82, rue du Gén. Leclerc

来源：

JOURNAL OF INFECTIOUS DISEASES | 1997年 / 175卷 / 01期

关键词：

D O I：

10.1093/infdis/175.1.172

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virus load in pregnancy and its relation to mother-to-child human immunodeficiency virus (HIV) transmission were studied prospectively. From 1989 to 1994, 320 HIV-infected women from 18 centers had plasma samples stored. Among women not receiving antiretroviral therapy, the polymerase chain reaction RNA level was 3.6 log at delivery, and 15% of women had levels below the detection limit. There was no variation during pregnancy. Women born in sub-Saharan Africa had lower RNA levels, although their CD4 cell distribution did not differ from that in other women. Among 236 evaluable children, 19% +/- 5% were infected. Transmission occurred in 12% of cases (confidence interval, 5%-22%) with < 1000 copies/mL versus 29% +/- 10% of those with > 10,000 copies/mL (P < .02). Maternal virus load appears strongly related to HIV transmission to the child.

引用

页码：172 / 175

页数：4

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