Proton magnetic resonance spectroscopy of late-life major depressive disorder

被引：43

作者：

Chen, Cheng-Sheng ^{[2
,3
,4
]}

Chiang, I-Chan ^{[1
]}

Li, Chun-Wei ^{[5
]}

Lin, Wei-Chen ^{[1
]}

Lu, Chia-Ying ^{[1
]}

Hsieh, Tsyh-Jyi ^{[1
]}

Liu, Gin-Chung ^{[1
,6
]}

Lin, Hsiu-Fen ^{[7
]}

Kuo, Yu-Ting ^{[1
,6
]}

机构：

[1] Kaohsiung Med Univ Hosp, Dept Med Imaging, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ Hosp, Dept Psychiat, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Psychiat, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan

[5] Coll Hlth Sci, Fac Med Radiat Technol, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Radiol, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung 807, Taiwan

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2009年 / 172卷 / 03期

关键词：

H-1-MRS; N-acetylaspartate; myo-inositol; Geriatric depression; ISCHEMIC VASCULAR DEMENTIA; N-ACETYLASPARTATE; LATE-ONSET;

D O I：

10.1016/j.pscychresns.2009.01.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The primary goal of this study was to examine the biochemical abnormalities of late-life major depression by using 3-tesla (3-T) proton magnetic resonance spectroscopy (H-1-MRS). The antidepressant effects on the biochemical abnormalities were investigated as well. Study participants were 27 elderly patients with major depressive disorders (among which 9 were on antidepressant medication) and 19 comparison elderly subjects. H-1-MRS spectra were acquired from voxels that were placed in the left frontal white matter, left periventricular white matter, and left basal ganglia. Ratios of N-acetylaspartate (NAA), choline (Cho) and myo-inositol to creatine were calculated. Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myoinositol/creatine ratios in the left basal ganglia when compared with the control subjects. The myoinositol correlated with global cognitive function among the patients. The biochemical abnormalities in late-life major depressive disorder were found on the left side of the frontal white matter and the basal ganglia. Neuron degeneration in the frontal white matter and second messenger system dysfunction or glial dysfunction in the basal ganglia are suggested to be associated with late-life depression. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：210 / 214

页数：5

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