Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjects

被引:21
作者
Valdes, Ignacio H.
Steinberg, Joel L.
Narayana, Ponnada A.
Kramer, Lany A.
Dougherty, Donald M.
Swann, Alan C.
Barratt, Ernest S.
Moeller, Frederick Gerard
机构
[1] Univ Texas, Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
[2] Univ Texas, Hlth Sci Ctr Houston, Dept Diagnost & Intervent Imaging, Houston, TX 77030 USA
[3] Wake Forest Univ Hlth Sci, Dept Psychiat & Behav Med, Winston Salem, NC 27109 USA
[4] Univ Texas, Med Branch, Dept Psychiat & Behav Sci, Galveston, TX 77555 USA
关键词
impulsivity; prefrontal; fMRI;
D O I
10.1016/j.pscychresns.2006.01.014
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The correlation between scores on the Barratt Impulsiveness Scale (BIS) and activation measured by functional magnetic resonance imaging in a dorsolateral prefrontal cortical (DLPFC) activating task was examined in 15 MDMA-using subjects and 19 controls. A significant correlation between BIS scores and DLPFC activation was found, supporting a role for the DLPFC in BIS-measured impulsivity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:239 / 242
页数:4
相关论文
共 17 条
[1]  
American Psychiatric Association (APA), 1994, DSM 4 DIAGN STAT MAN
[2]  
[Anonymous], 2002, NEUROIMAGE
[3]   Prefrontal cortex and decision making in a mixed-strategy game [J].
Barraclough, DJ ;
Conroy, ML ;
Lee, D .
NATURE NEUROSCIENCE, 2004, 7 (04) :404-410
[4]   Impulsivity, time perception, emotion and reinforcement sensitivity in patients with orbitofrontal cortex lesions [J].
Berlin, HA ;
Rolls, ET ;
Kischka, U .
BRAIN, 2004, 127 :1108-1126
[5]   Angry cognitive bias, trait aggression and impulsivity in substance users [J].
Bond, AJ ;
Verheyden, SL ;
Wingrove, J ;
Curran, HV .
PSYCHOPHARMACOLOGY, 2004, 171 (03) :331-339
[6]   Immediate and delayed memory tasks: A computerized behavioral measure of memory, attention, and impulsivity [J].
Dougherty, DM ;
Marsh, DM ;
Mathias, CW .
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS, 2002, 34 (03) :391-398
[7]  
Friston K.J., 1994, Human Brain Mapping, V2, P189, DOI DOI 10.1002/HBM.460020402
[8]  
GASER C, 2005, RE CORRELATION COEFF
[9]   Executive dysfunction in cocaine addiction: Evidence for discordant frontal, cingulate, and cerebellar activity [J].
Hester, R ;
Garavan, H .
JOURNAL OF NEUROSCIENCE, 2004, 24 (49) :11017-11022
[10]   Functional MRI study of working memory in MDMA users [J].
Moeller, FG ;
Steinberg, JL ;
Dougherty, DM ;
Narayana, PA ;
Kramer, LA ;
Renshaw, PF .
PSYCHOPHARMACOLOGY, 2004, 177 (1-2) :185-194