Oncogenic stress sensed by the immune system: role of natural killer cell receptors

被引：304

作者：

Raulet, David H. ^{[1
]}

Guerra, Nadia ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Canc Res Lab, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 08期

基金：

美国国家卫生研究院;

关键词：

DELTA-T-CELLS; HUMAN NK CELLS; I-RELATED CHAIN; ACTIVATING NKG2D RECEPTOR; DNA-DAMAGE RESPONSE; INTERFERON-GAMMA; CUTTING EDGE; TUMOR-CELLS; DOWN-REGULATION; RETINOIC-ACID;

D O I：

10.1038/nri2604

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A growing body of research is addressing how pathways that are dysregulated during tumorigenesis are linked to innate immune responses, which can contribute to immune surveillance of cancer. Components of the innate immune system that are localized in tissues are thought to eliminate early neoplastic cells, thereby preventing or delaying the establishment of advanced tumours. This Review addresses our current understanding of the mechanisms that detect cellular stresses that are associated with tumorigenesis and that culminate in the recognition and, in some cases, the elimination of the tumour cells by natural killer cells and other lymphocytes that express natural killer cell receptors.

引用

页码：568 / 580

页数：13

共 148 条

[1] Cell cycle checkpoint signaling through the ATM and ATR kinases [J].

Abraham, RT .

GENES & DEVELOPMENT, 2001, 15 (17) :2177-2196

[2] Function and regulation of AP-1 subunits in skin physiology and pathology [J].

Angel, P ;

Szabowski, A ;

Schorpp-Kistner, M .

ONCOGENE, 2001, 20 (19) :2413-2423

[3] Tumor and viral recognition by natural killer cells receptors [J].

Arnon, Tal I. ;

Markel, Gal ;

Mandelboim, Ofer .

SEMINARS IN CANCER BIOLOGY, 2006, 16 (05) :348-358

[4] Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease [J].

Azimi, N ;

Jacobson, S ;

Tanaka, Y ;

Corey, L ;

Groh, V ;

Spies, T .

IMMUNOGENETICS, 2006, 58 (04) :252-258

[5] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis [J].

Bartkova, J ;

Horejsi, Z ;

Koed, K ;

Krämer, A ;

Tort, F ;

Zieger, K ;

Guldberg, P ;

Sehested, M ;

Nesland, JM ;

Lukas, C ;

Orntoft, T ;

Lukas, J ;

Bartek, J .

NATURE, 2005, 434 (7035) :864-870

[6] Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA [J].

Bauer, Stefan ;

Groh, Veronika ;

Wu, Jun ;

Steinle, Alexander ;

Phillips, Joseph H. ;

Lanier, Lewis L. ;

Spies, Thomas .

JOURNAL OF IMMUNOLOGY, 2018, 200 (07) :2231-2233

[7] Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46 [J].

Bloushtain, N ;

Qimron, U ;

Bar-Ilan, A ;

Hershkovitz, O ;

Gazit, R ;

Fima, E ;

Korc, M ;

Vlodavsky, I ;

Bovin, NV ;

Porgador, A .

JOURNAL OF IMMUNOLOGY, 2004, 173 (04) :2392-2401

[8] 2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes [J].

Boles, KS ;

Stepp, SE ;

Bennett, M ;

Kumar, V ;

Mathew, PA .

IMMUNOLOGICAL REVIEWS, 2001, 181 :234-249

[9] Identification of PVR (CD155) and nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule [J].

Bottino, C ;

Castriconi, R ;

Pende, D ;

Rivera, P ;

Nanni, M ;

Carnemolla, B ;

Cantoni, C ;

Grassi, J ;

Marcenaro, S ;

Reymond, N ;

Vitale, M ;

Moretta, L ;

Lopez, M ;

Moretta, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (04) :557-567

[10] Cutting Edge: The Metalloproteinase ADAM17/TNF-α-Converting Enzyme Regulates Proteolytic Shedding of the MHC Class I-Related Chain B Protein [J].

Boutet, Philippe ;

Agura-Gonzalez, Sonia ;

Atkinson, Susan ;

Pennington, Caroline J. ;

Edwards, Dylan R. ;

Murphy, Gillian ;

Reyburn, Hugh T. ;

Vales-Gomez, Mar .

JOURNAL OF IMMUNOLOGY, 2009, 182 (01) :49-53

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