Toxicological applications of magnetic resonance

被引：86

作者：

Lindon, JC ^{[1
]}

Holmes, E ^{[1
]}

Nicholson, JK ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Biomed Sci, London SW7 2AZ, England

来源：

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | 2004年 / 45卷 / 1-2期

关键词：

NMR; MRI; MRS; toxicology; tumour; cytotoxicity; metabonomics; biofluids; histopathology; pharmaceuticals; magic-angle-spinning;

D O I：

10.1016/j.pnmrs.2004.05.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The toxicological applications of nuclear magnetic resonance spectroscopy in biomedical science, are discussed. Metabonomics is an approach for studying toxicity because toxins cause perturbation of the concentrations and fluxes of endogeneous metabolites involved in key cellular pathway. THe response of cells to toxic stressors generally results in an adjustments of their extra-cellular environment in order of their internal environment. The relationship between blood manganese concentrations and bran lesions was also examined, as indicated by clinical examination and MRI.

引用

页码：109 / 143

页数：35

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