Overexpression of soluble vascular endothelial growth factor receptor 1 in colorectal cancer: Association with progression and prognosis

被引:49
作者
Yamaguchi, Tatsuro
Bando, Hiroko
Mori, Takeo
Takahashi, Keiichi
Matsumoto, Hiroshi
Yasutome, Michiya
Weich, Herbert A.
Toi, Masakazu [1 ]
机构
[1] Tokyo Metropolitan Komagome Hosp, Dept Surg, Tokyo Metropolitan Canc & Infect Dis Ctr, Tokyo 1138677, Japan
[2] Tsukuba Univ Hosp, Dept Surg, Tsukuba, Ibaraki 3058577, Japan
[3] Natl Res Ctr Biotechnol, Dept Gene Regulat & Differentiat, D-38124 Braunschweig, Germany
[4] Tokyo Metropolitan Komagome Hosp, Dept Clin Trials & Res, Tokyo Metropolitan Canc & Infect Dis Ctr, Tokyo 1138677, Japan
关键词
D O I
10.1111/j.1349-7006.2007.00402.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We examined the expression of sVEGFR1 in colorectal cancer tissue and corresponding normal colorectal mucosa to assess the clinical significance of sVEGFR1 in colorectal cancer. We also assessed the relationship between sVEGFR1 levels and various clinicopathologic factors and prognoses. sVEGFR1 and VEGF levels were measured in fresh-frozen tumor extracts from 84 primary colorectal cancer tissues and 27 corresponding normal mucosa using ELISA. Mean of sVEGFR1 levels were 3.17 ng/mg protein. sVEGFR1 levels increased significantly in cancer tissue compared with normal mucosa. Although VEGF levels increased in cancer tissues, the ratio of sVEGFR1/VEGF in cancer tissue was significantly lower than that in normal tissue. No significant correlation between sVEGFR1 or VEGF levels and any clinicopathologic parameter was found. Overexpression of sVEGFR1 was significantly associated with a favorable prognosis. Based on sVEGFR1 levels in colorectal cancer without distant metastases, patients with higher sVEGFR1 levels (>= 1.5 ng/mg protein) demonstrated significant longer recurrence-free survival than patients with lower sVEGFR1 levels (< 1.5 ng/mg protein) (P = 0.0017). Multivariate analysis showed that the sVEGFR1 levels in cancer tissue were an independent prognostic indicator of disease progression. sVEGFR1 expression was significantly elevated in colorectal cancer tissue compared with normal mucosa and the intratumoral balance between sVEGFR1 and VEGF was significantly different between tumor tissue and normal controls. Furthermore, sVEGFR1 levels showed a significant prognostic value. Further studies concerning the biologic and therapeutic significance of sVEGFR1 in colorectal cancer are warranted.
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页码:405 / 410
页数:6
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