Human genes that limit AIDS

被引：229

作者：

O'Brien, SJ ^{[1
]}

Nelson, GW

机构：

[1] NCI, Lab Genom Divers, Frederick, MD 21701 USA

[2] SAIC Frederick, Basic Res Program, Lab Genom Divers, NIC, Frederick, MD USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 06期

关键词：

D O I：

10.1038/ng1369

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Discernable genetic variation among people and populations has an important role in infectious disease epidemics, including that of acquired immune deficiency syndrome (AIDS). Genetic association analysis of several large AIDS cohorts implicate 14 AIDS restriction genes, polymorphic variants in loci that regulate HIV-1 cell entry, acquired and innate immunity, and cytokine defenses to HIV-1. The influence and translational impact of these genes on individual and population sensitivity to AIDS is considerable.

引用

页码：565 / 574

页数：10

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