Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor

被引：71

作者：

Jazin, EE

Soderstrom, B

Ebendal, T

Larhammar, D

机构：

[1] UNIV UPPSALA,DEPT DEV NEUROSCI,S-75123 UPPSALA,SWEDEN

[2] UNIV UPPSALA,DEPT MED PHARMACOL,S-75123 UPPSALA,SWEDEN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1997年 / 79卷 / 02期

关键词：

fusin; CXCR-4; receptor; lymphocyte chemoattractant; HIV; rat development;

D O I：

10.1016/S0165-5728(97)00117-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously cloned a human receptor recently shown to be a cofactor for entry of T = tropic HIV-1 strains into CD4 + cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny in the rat. The onset of mRNA expression is around embryonic day 9 and the mRNA expression is high in the thymus as well as proliferative areas of the brain during development. Our results su est: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development. (C) 1997 Elsevier Science B.V.

引用

收藏

页码：148 / 154

页数：7

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