Intestinal pathology during acute toxoplasmosis is IL-4 dependent and unrelated to parasite burden

被引:20
作者
Nickdel, MB
Lyons, RE
Roberts, F
Brombacher, F
Hunter, CA
Alexander, J
Roberts, CW [1 ]
机构
[1] Univ Strathclyde, Strathclyde Inst Biomed Sci, Dept Immunol, Glasgow G4 0NR, Lanark, Scotland
[2] Univ Glasgow, Western Infirm, Glasgow G11 6NT, Lanark, Scotland
[3] Univ Cape Town, Hlth Fac, Dept Immunol, ZA-7700 Rondebosch, South Africa
[4] Univ Penn, Dept Pathobiol, Philadelphia, PA 19104 USA
关键词
parasitic protozoan; Th1/Th2; cells; mucosa; cytokines;
D O I
10.1111/j.0141-9838.2004.00686.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The role of interleukin-4 (IL-4) during the course of Toxoplasma gondii infection was studied using IL-4-/- mice and their wild-type (WT) counterparts on a C57BL/6 background. Following oral infection with T. gondii tissue cysts an exacerbative role for IL-4 was demonstrated and IL-4-/- mice were found to be more resistant to infection than WT mice as measured by significantly reduced mortality. Furthermore pathology in the small intestine was less severe in IL-4-/- mice although conversely liver pathology was greater than in wild-type mice. Significantly, plasma IL-12 and IFN-gamma levels, which peaked at days 6 and 8, respectively, were higher in IL-4-/- mice. The exacerbatory role of IL-4 in the intestine was found by competitive RT-PCR not to be associated with increased parasite burdens but was related to comparative expression of IL-10.
引用
收藏
页码:75 / 82
页数:8
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