Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

被引：375

作者：

Song, Min Jeong ^{[1
]}

Kim, Kang Ho ^{[1
]}

Yoon, Jeong Min ^{[1
]}

Kim, Jae Bum ^{[1
]}

机构：

[1] Seoul Natl Univ, Res Ctr Funct Cellulom, Dept Biol Sci, Seoul 151742, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 346卷 / 03期

关键词：

TLR4; obesity; inflammation; adipocytes; free fatty acids; insulin resistance;

D O I：

10.1016/j.bbrc.2006.05.170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic inflammation is closely associated with metabolic disorders such as obesity and type 2 diabetes, however, the underlying mechanism is unclear. Toll-like receptors (TLRs) play a key role in innate immune response as well as inflammatory signals. Here, we observed that mRNA level of TLR4 was induced during adipocyte differentiation and remarkably enhanced in fat tissues of obese db/db mice. In addition, activation of TLR4 with either LPS or free fatty acids stimulated NF kappa B signaling and expression of inflammatory cytokine genes, such as TNF alpha and IL-6 in 3T3-L1 adipocytes. Furthermore, we discovered that TLR4 activation in 3T3-L1 adipocytes provoked insulin resistance. Taken together, these results suggest that activation of TLR4 in adipocyte might be implicated in the onset of insulin resistance in obesity and type 2 diabetes. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：739 / 745

页数：7

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