High but not low ECS stimulus intensity augments apomorphine-stimulated dopamine postsynaptic receptor functioning in rats

被引:8
作者
Andrade, C [1 ]
Srinivasamurthy, GM [1 ]
Vishwasenani, A [1 ]
Prakash, GS [1 ]
Srihari, BS [1 ]
Chandra, JS [1 ]
机构
[1] Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataka, India
关键词
electroconvulsive therapy; electroconvulsive shock; electrical dose; dopamine receptors; apomorphine; seizure duration; rats;
D O I
10.1097/00124509-200206000-00003
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Background: Clinical research shows that the antidepressant and cognitive adverse effects of electroconvulsive therapy are both dependent on the administered electrical stimulus intensity (dose); however, dose-dependent neurotransmitter system changes in the brain, which might underlie the therapeutic or adverse effects, remain to be demonstrated. Objective: We used a behavioral model to examine dose-related effects of electroconvulsive shock (ECS) on dopamine postsynaptic receptor functioning in the rat brain. Methods: In a factorially designed study, rats (n = 100) were treated with five once-daily ECSs at three levels (sham ECS, 30 mC ECS, and 120 mC ECS), and with drug at two levels (saline, and I mg/kg s.c. apomorphine). Motility was assessed in the small open field. Results: Apomorphine-elicited, dopamine postsynaptic receptor-mediated hypermotility was significantly increased by 120 mC ECS but not by 30 mC ECS. An additional but unrelated finding was that, while the ECS seizure duration expectedly decreased across time, no dose-dependent effects were observed. Conclusion: ECS-induced dopamine postsynaptic receptor up-regulation may depend on the intensity of the administered electrical stimulus.
引用
收藏
页码:80 / 83
页数:4
相关论文
共 21 条
  • [1] Andrade C, 1993, Indian J Psychiatry, V35, P43
  • [2] Effects of stimulus parameters on seizure duration and ECS-induced retrograde amnesia
    Andrade, C
    Suresh, S
    Krishnan, J
    Venkataraman, BV
    [J]. JOURNAL OF ECT, 2002, 18 (01) : 31 - 37
  • [3] Andrade C, 1997, NIMHANS J, V15, P319
  • [4] Quantifying the ECT dose: The right unit remains elusive
    Andrade, C
    [J]. JOURNAL OF ECT, 2001, 17 (01) : 75 - 75
  • [5] Andrade C., 1995, METHODS BIOL PSYCHIA, P114
  • [6] ANDRADE C, 1990, NIMHANS J, V8, P53
  • [7] STUDIES ON POSSIBLE MECHANISMS OF ACTION OF ELECTROCONVULSIVE-THERAPY - EFFECTS OF REPEATED ELECTRICALLY INDUCED SEIZURES ON RAT-BRAIN RECEPTORS FOR MONOAMINES AND OTHER NEUROTRANSMITTERS
    DEAKIN, JFW
    OWEN, F
    CROSS, AJ
    DASHWOOD, MJ
    [J]. PSYCHOPHARMACOLOGY, 1981, 73 (04) : 345 - 349
  • [8] FOCHTMANN LJ, 1994, CONVULSIVE THER, V10, P287
  • [9] FOCHTMANN LJ, 1994, PSYCHOPHARMACOL BULL, V30, P321
  • [10] Inverse relation between stimulus intensity and seizure duration: Implications for ECT procedure
    Frey, R
    Heiden, A
    Scharfetter, J
    Schreinzer, D
    Blasbichler, T
    Tauscher, J
    Felleiter, P
    Kasper, S
    [J]. JOURNAL OF ECT, 2001, 17 (02) : 102 - 108