Soluble factors and the development of rod photoreceptors

被引:93
作者
Levine, EM [1 ]
Fuhrmann, S [1 ]
Reh, TA [1 ]
机构
[1] Univ Washington, Sch Med, Dept Biol Struct, Seattle, WA 98195 USA
关键词
retina; signaling factors; retinoic acid; hedgehog; fibroblast growth factor; epidermal growth factor; ciliary neurotrophic factor;
D O I
10.1007/PL00000686
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Photoreceptors are the most abundant cell type in the vertebrate neural retina. Like the other retinal neurons and the Muller glia, they arise from a population of precursor cells that are multipotent and intrinsic to the retina. Approximately 10 years ago, several studies demonstrated that retinal precursor cells (RPCs) are competent to respond to environmental factors that promote cell type determination and differentiation. Since those studies, significant effort has been directed at identifying the molecular nature of these environmental signals and understanding the precise mechanisms they employ to drive RPCs towards the different retinal fates. In this review, we describe the recent progress toward understanding how environmental factors influence the development of vertebrate rod photoreceptors.
引用
收藏
页码:224 / 234
页数:11
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