Synthesis of N-Boc-(R)-α-phenyl-γ-aminobutyric acid using an in situ diastereoselective protonation strategy

被引：7

作者：

Calmés, M

Escale, F

Martinez, J

机构：

[1] Univ Montpellier I, CNRS, UMR 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 5, France

[2] Univ Montpellier 2, CNRS, UMR 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 5, France

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(02)00075-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of (+/-)-N-phthalyl alpha-phenyl-gamma-aminobutyric acid and its asymmetric transformation via ketene formation have been investigated, allowing, after hydrolysis and amine protection, the preparation of the enantiomerically pure N-Boc-(R)-alpha-phenyl-gamma-aminobutyric acid. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：293 / 296

页数：4

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