Stereoselective reduction of unsaturated 1,4-diketones. A practical route to chiral 1,4-diols

被引：33

作者：

Bach, J ^{[1
]}

Berenguer, R ^{[1
]}

Garcia, J ^{[1
]}

Loscertales, T ^{[1
]}

Manzanal, J ^{[1
]}

Vilarrasa, J ^{[1
]}

机构：

[1] UNIV BARCELONA, DEPT QUIM ORGAN, DIV 3, E-08028 BARCELONA, CATALONIA, SPAIN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(96)02476-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthetic route to C-2-symmetric chiral 1,4-diols based on the borane-mediated oxazaborolidine-catalysed reduction of 2-ene-1,4-diones (2), of 2-yne-1,4-diones (3), and/or of Co-complexed diketones 4 is described. Good to excellent enantio- and diastereoselectivities have been obtained in the reduction of diketones 3 and 4, catalysed by ozazaborolidines 6 and 5, respectively. (C) 1997, Elsevier Science Ltd.

引用

页码：1091 / 1094

页数：4

共 25 条

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