Somatic mutations and aging: a re-evaluation

被引:185
作者
Vijg, J
机构
[1] Canc Therapy & Res Ctr S Texas, Dept Basic Res, San Antonio, TX 78229 USA
[2] Univ Texas, Hlth Sci Ctr, San Antonio, TX 78229 USA
基金
美国国家卫生研究院;
关键词
somatic mutation; aging; DNA repair; transgenic and knockout mice; genome instability;
D O I
10.1016/S0027-5107(99)00202-X
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin resting this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:117 / 135
页数:19
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