A convenient synthesis of enaminones using tandem acetonitrile condensation, Grignard addition

被引：23

作者：

Haight, AR

Stuk, TL

Menzia, JA

Robbins, TA

机构：

[1] Chemical Process Research, D54P, Abbott Laboratories, North Chicago

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(97)00866-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensations of N,N-dibenzyl alpha-amino esters with the anion of acetonitrile followed by the addition of a Grignard reagent proceed in excellent yields. This affords rapid access to the peptidomimetic precursor alpha-amino enaminones in one pot from the esters. (C) 1997 Elsevier Science Ltd.

引用

页码：4191 / 4194

页数：4

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