CD8 T cells are sufficient to mediate allorecognition and allograft rejection

被引：16

作者：

Halamay, KE

Kirkman, RL

Sun, LH

Yamada, A

Fragoso, RC

Shimizu, K

Mitchell, RN

McKay, DB

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol,Div Pediat, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Renal & Transplantat Div, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Surg, Boston, MA 02115 USA

[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Cardiovasc Med, Boston, MA 02115 USA

[6] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

[7] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Surg,Transplantat Unit, Boston, MA 02114 USA

来源：

CELLULAR IMMUNOLOGY | 2002年 / 216卷 / 1-2期

关键词：

CD8 T cells; allorecognition; transplantation; acute allograft rejection; transgenic mouse; 2C mouse;

D O I：

10.1016/S0008-8749(02)00530-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Different T cell subsets may play different roles in allorecognition and allograft rejection. It has been suggested that CD8 T cells can only initiate rejection with help from CD4 T cells. Since CD8 T cells may have different requirements for allorecognition and for costimulation. it is important to clarify the role of CD8 cells in rejection. We examined the role of CD8 cells in allorecognition using a TCR transgenic mouse transplantation model. In our study, CD8 cells were able to recognize alloantigens and reject allografts in the absence of help from CD4 T cells. Furthermore our study provides a model to study the mechanisms of CD8-mediated allograft rejection. It may be important in the future, to consider that CD8 T cells may need to be targeted independently of CD4 T cells in strategies used to prevent rejection and induce tolerance. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：6 / 14

页数：9

共 33 条

[1]

BACHMANN MF, 1995, J IMMUNOL, V155, P3727

[2]

Billingham M E, 1990, J Heart Transplant, V9, P587

[3]

Chen FL, 1996, J IMMUNOL, V156, P2036

[4] THE INDUCTION OF SKIN-GRAFT TOLERANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX-MISMATCHED OR PRIMED RECIPIENTS - PRIMED T-CELLS CAN BE TOLERIZED IN THE PERIPHERY WITH ANTI-CD4 AND ANTI-CD8 ANTIBODIES [J].