New disc-based technologies for diagnostic and research applications

被引：27

作者：

Barathur, R ^{[1
]}

Bookout, J ^{[1
]}

Sreevatsan, S ^{[1
]}

Gordon, J ^{[1
]}

Werner, M ^{[1
]}

Thor, G ^{[1
]}

Worthington, M ^{[1
]}

机构：

[1] Burstein Technol Inc, Irvine, CA 92618 USA

来源：

PSYCHIATRIC GENETICS | 2002年 / 12卷 / 04期

关键词：

CD/DVD discs; genotyping; gene variants; MEMS; microarrays; nanotechnology; neurogenomics; neurologic disorders; optical discs; pathogen detection; pharmacogenomics;

D O I：

10.1097/00041444-200212000-00002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The role of genotypic analysis in disease diagnostics and drug response assessment is continually expanding. New genomic discoveries combined with new, novel technologies may provide a greater range of testing capabilities in the near future. We describe the application of nanotechnology, in which DNA microarrays have been placed in a microchannel environment that can be read and analyzed in an optical (CD/DVD) disc drive system. The potential exists to combine molecular and immunological applications together into a rapid, low-cost, high-capacity screening platform. The relevance of this technology is discussed in respect to infectious agent detection, pharmacogenomics, neurogenomics and genetic variations associated with neurologic diseases. (C) 2002 Lippincott Williams Wilkins.

引用

页码：193 / 206

页数：14

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