Stimulant-like action of nicotine on striatal dopamine transporter in the brain of adults with attention deficit hyperactivity disorder

被引：66

作者：

Krause, KH

Dresel, SH

Krause, J

Kung, HF

Tatsch, K

Ackenheil, M

机构：

[1] Univ Munich, Friedrich Baur Inst, D-80336 Munich, Germany

[2] Univ Munich, Dept Nucl Med, D-80336 Munich, Germany

[3] Outpatient Clin Psychiat & Psychotherapy, D-85521 Ottobrunn, Germany

[4] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[5] Univ Munich, Dept Neurochem, D-80336 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2002年 / 5卷 / 02期

关键词：

attention deficit hyperactivity disorder (ADHD); dopamine transporter; nicotine; single photon emission computed tomography (SPECT); TRODAT-1;

D O I：

10.1017/S1461145702002821

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7-40 cigarettes per day, showed statistically significant lower values for striatal dopamine transporter (DAT) measured by [Tc-99m]TRODAT-I SPECT compared to 11 non-smoking drug-naive patients with ADHD, matched for sex and age, despite higher ADHD scores for the smokers. Because stimulants have been shown to reduce primarily elevated DAT density in adults with ADHD, it can be suggested that nicotine acts in a similar way on striatal DAT as do stimulants.

引用

页码：111 / 113

页数：3

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