Intercellular Junctional Proteins as Receptors and Barriers to Virus Infection and Spread

被引：55

作者：

Bergelson, Jeffrey M. ^{[1
,2
]}

机构：

[1] Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USA

[2] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

来源：

CELL HOST & MICROBE | 2009年 / 5卷 / 06期

关键词：

HEPATITIS-C VIRUS; EPITHELIAL TIGHT JUNCTIONS; COXSACKIEVIRUS ENTRY; HEPATOCYTES; EXPRESSION; CLAUDIN-1; REOVIRUS; OCCLUDIN;

D O I：

10.1016/j.chom.2009.05.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Most viruses infect their hosts by crossing the mucosal surfaces of the respiratory, gastrointestinal, or genital tracts, then spread-often through the bloodstream-to other organs; they are shed in bodily secretions to reach new hosts. At each stage in the cycle of infection viruses surmount significant anatomic barriers. This Minireview focuses on the role of intercellular junctions as barriers to virus dissemination, and the somewhat paradoxical observation that several viruses, rather than evading these barriers, target them directly by using junctional proteins as receptors.

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页码：517 / 521

页数：5

相关论文

共 20 条

[1] Tight junctions: Molecular architecture and function [J].

Aijaz, S ;

Balda, MS ;

Matter, K .

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 248, 2006, 248 :261-298

[2] Junctional Adhesion Molecule-A Is Required for Hematogenous Dissemination of Reovirus [J].

Antar, Annukka A. R. ;

Konopka, Jennifer L. ;

Campbell, Jacquelyn A. ;

Henry, Rachel A. ;

Perdigoto, Ana L. ;

Carter, Bruce D. ;

Pozzi, Ambra ;

Abel, Ty W. ;

Dermody, Terence S. .

CELL HOST & MICROBE, 2009, 5 (01) :59-71

[3] Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis [J].

Bazzoni, G ;

Dejana, E .

PHYSIOLOGICAL REVIEWS, 2004, 84 (03) :869-901

[4] Virus interactions with mucosal surfaces: alternative receptors, alternative pathways [J].

Bergelson, JM .

CURRENT OPINION IN MICROBIOLOGY, 2003, 6 (04) :386-391

[5] CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes [J].

Brazzoli, Michela ;

Bianchi, Alessia ;

Filippini, Sara ;

Weiner, Amy ;

Zhu, Qing ;

Pizza, Mariagrazia ;

Crotta, Stefania .

JOURNAL OF VIROLOGY, 2008, 82 (17) :8316-8329

[6] Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5 [J].

Coyne, Carolyn B. ;

Le Shen ;

Turner, Jerrold R. ;

Bergelson, Jeffrey M. .

CELL HOST & MICROBE, 2007, 2 (03) :181-192

[7] Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions [J].

Coyne, CB ;

Bergelson, JM .

CELL, 2006, 124 (01) :119-131

[8] Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry [J].

Evans, Matthew J. ;

von Hahn, Thomas ;

Tscherne, Donna M. ;

Syder, Andrew J. ;

Panis, Maryline ;

Woelk, Benno ;

Hatziioannou, Theodora ;

McKeating, Jane A. ;

Bieniasz, Paul D. ;

Rice, Charles M. .

NATURE, 2007, 446 (7137) :801-805

[9] Reovirus receptors and pathogenesis [J].

Forrest, JC ;

Dermody, TS .

JOURNAL OF VIROLOGY, 2003, 77 (17) :9109-9115

[10]

Helenius A, 2007, FIELDS VIROLOGY, P99