Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis

被引：2

作者：

Omata, T ^{[1
]}

Itokazu, Y ^{[1
]}

Inoue, N ^{[1
]}

Segawa, Y ^{[1
]}

机构：

[1] Zeria Pharmaceut Co Ltd, Cent Res Labs, Dept Appl Res, Khonan, Saitama 3600111, Japan

来源：

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH | 2000年 / 50卷 / 02期

关键词：

CAS; 25322-46-7; chondroitin sulfate-C; Chondroitin ZS Tab; effects on articular cartilage destruction; mouse; collagen-induced arthritis;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effects of chondroitin sulfate-C (CAS 25322-46-7, Chondroitin ZS Tab) on type II collagen (CII)-induced arthritis (CIA) in mice were evaluated. DBA/1J mice were immunized with bovine CII emulsified in Freund's complete adjuvant, followed by a booster injection 21 days later. Chondroitin sulfate-C at doses of 100, 300 and 1000 mg/kg was administered orally once daily beginning 14 days before initial immunization. An arthritis index and hind paw edema were examined from day 0 to day 49, when the mice were killed by ether anesthesia for histopathological examination. The delayed-type hypersensitivity (DTH) reaction, serum anti-CII antibody titer, and histopathologic characteristics of both synovitis and destruction of articular cartilage were analyzed. Both the arthritis index and the serum anti-CII antibody titer were reduced by treatment with chondroitin sulfate-C ina dose-dependent manner. Chondroitin sulfate-C (1000 mg/kg) significantly inhibited hind paw edema, synovitis and destruction of the articular cartilage, burnet DTH reaction.

引用

页码：148 / 153

页数：6

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