Magnolol Enhances Pentobarbital-induced Sleeping Behaviors: Possible Involvement of GABAergic Systems

被引：24

作者：

Ma, Hong ^{[1
]}

Kim, Chung-Soo ^{[1
]}

Ma, Yuan ^{[2
]}

Nam, Sang-Yoon ^{[2
]}

Kim, Dong-Seon ^{[3
]}

Woo, Sung-Sick ^{[3
]}

Hong, Jin-Tae ^{[1
]}

Oh, Ki-Wan ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

[2] Chungbuk Natl Univ, Vet Med Res Inst, Cheongju 361763, South Korea

[3] UniGem Inc, Byeongcheon Myeon, Cheonan Si 330863, Chungnam, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 09期

关键词：

magnolol; pentobarbital; sleep; chloride influx; GABA(A) receptors; glutamic acid decarboxylase (GAD); ZIZYPHI-SPINOSI SEMEN; GABA(A) RECEPTORS; HONOKIOL; EXTRACT; OFFICINALIS; SUBTYPES; ASSAY;

D O I：

10.1002/ptr.2773

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study was performed to investigate whether magnolol enhances pentobarbital-induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The expression of the GABA(A) receptor alpha-subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of beta- or gamma-subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital-induced sleeping behaviors through the activation of GABAergic systems. Copyright (c) 2009 John Wiley & Sons, Ltd.

引用

页码：1340 / 1344

页数：5

共 33 条

[1] Honokiol and magnolol selectively interact with GARAA receptor subtypes in vitro [J].

Ai, JL ;

Wang, XM ;

Nielsen, M .

PHARMACOLOGY, 2001, 63 (01) :34-41

[2] General anaesthetic action at transmitter-gated inhibitory amino acid receptors [J].

Belelli, D ;

Pistis, M ;

Peters, JA ;

Lambert, JJ .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (12) :496-502

[3] Deletion of the α1 or β2 subunit of GABAA receptors reduces actions of alcohol and other drugs [J].

Blednov, YA ;

Jung, S ;

Alva, H ;

Wallace, D ;

Rosahl, T ;

Whiting, PJ ;

Harris, RA .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 304 (01) :30-36

[4] GABA-activated ligand gated ion channels: Medicinal chemistry and molecular biology [J].

Chebib, M ;

Johnston, GAR .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (08) :1427-1447

[5]

Darias V, 1998, PHARMAZIE, V53, P477

[6]

GEE KW, 1995, CRIT REV NEUROBIOL, V9, P207

[7] GABA mechanisms and sleep [J].

Gottesmann, C .

NEUROSCIENCE, 2002, 111 (02) :231-239

[8]

Han Huishan, 2007, Journal of Applied Pharmacology, V15, P175

[9] CaMK-II modulation of GABAA receptors expressed in HEK293, NG108-15 and rat cerebellar granule neurons [J].

Houston, C. M. ;

Smart, T. G. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 24 (09) :2504-2514

[10] Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: A qualitative and quantitative electrophysiological and histopathological study [J].

Kakinohana, O. ;

Hefferan, M. P. ;

Nakamura, S. ;

Kakinohana, M. ;

Galik, J. ;

Tomori, Z. ;

Marsala, J. ;

Yaksh, T. L. ;

Marsala, M. .

NEUROSCIENCE, 2006, 141 (03) :1569-1583

← 1 2 3 4 →