Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding

被引：55

作者：

Noble, Wendy ^{[1
]}

Garwood, Claire J. ^{[1
]}

Hanger, Diane P. ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, Dept Neurosci, MRC Ctr Neurodegenerat Res, London SE5 8AF, England

来源：

PRION | 2009年 / 3卷 / 02期

关键词：

minocycline; protein aggregation; neuroinflammation; neurodegeneration; protein misfolding; AMYOTROPHIC-LATERAL-SCLEROSIS; SLOWS DISEASE PROGRESSION; MOUSE MODEL; MICROGLIAL ACTIVATION; PRION PROTEIN; CELL-DEATH; A-BETA; ALZHEIMERS; TAU; TETRACYCLINES;

D O I：

10.4161/pri.3.2.8820

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Many neurodegenerative disorders share common features including the accumulation of aggregated misfolded proteins, neuroinflammation and the induction of apoptosis. While the contributions of each of these individual elements to neuronal death remain unclear, a commonly used antibiotic, minocycline, has been shown to reduce the progression and severity of disease in several models of neurodegeneration by variously downregulating these molecular pathways. Here we discuss the evidence for the potential of minocycline as a broad-specificity therapeutic agent for those neurodegenerative diseases that are characterized by the presence of misfolded proteins.

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页码：78 / 83

页数：6

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