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Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders

被引：147
作者：
Agarwal, Swati [1 ,2 ]
Yadav, Anuradha [1 ,2 ]
Chaturvedi, Rajnish Kumar [1 ,2 ]
机构：
[1] CSIR, IITR, Syst Toxicol & Hlth Risk Assessment Grp, Dev Toxicol Lab, 31 Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India
[2] Acad Sci & Innovat Res AcSIR, CSIR IITR Lucknow Campus, Lucknow, Uttar Pradesh, India
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2017年 / 483卷 / 04期
关键词：
Mitochondrial dysfunction; Neurodegenerative disorder; Mitochondrial dynamics; PGC-1; alpha; Mitochondrial biogenesis; Pioglitazone; Rosiglitazone; TRANSGENIC MOUSE MODEL; NF-KAPPA-B; NEUROBLASTOMA SH-SY5Y CELLS; GAMMA AGONIST PIOGLITAZONE; FATTY-ACID OXIDATION; RETINOID-X-RECEPTOR; P38 MAP KINASE; PARKINSONS-DISEASE; MITOCHONDRIAL DYSFUNCTION; DOPAMINERGIC-NEURONS;
D O I：
10.1016/j.bbrc.2016.08.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要：
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to be a promising therapeutic target for several neurodegenerative disorders, which includes Parkinson disease, Alzheimer's disease, Huntington disease and Amyotrophic Lateral Sclerosis. PPARs play an important role in the downregulation of mitochondrial dysfunction, proteasomal dysfunction, oxidative stress, and neuroinflammation, which are the major causes of the pathogenesis of neurodegenerative disorders. In this review, we discuss about the role of PPARs as therapeutic targets in neurodegenerative disorders. Several experimental approaches suggest potential application of PPAR agonist as well as antagonist in the treatment of neurodegenerative disorders. Several epidemiological studies found that the regular usage of PPAR activating non-steroidal anti-inflammatory drugs is effective in decreasing the progression of neurodegenerative diseases including PD and AD. We also reviewed the neuroprotective effects of PPAR agonists and associated mechanism of action in several neurodegenerative disorders both in vitro as well as in vivo animal models. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：1166 / 1177
页数：12
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